Literature DB >> 22318598

Infectious disease: Genomics decodes drug action.

Alan H Fairlamb.   

Abstract

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22318598     DOI： 10.1038/482167a

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


× No keyword cloud information.
  11 in total

Review 1.  Mechanisms of gene silencing by double-stranded RNA.

Authors:  Gunter Meister; Thomas Tuschl
Journal:  Nature       Date:  2004-09-16       Impact factor: 49.962

Review 2.  Macromolecular trafficking and immune evasion in african trypanosomes.

Authors:  Mark C Field; Jennifer H Lumb; Vincent O Adung'a; Nicola G Jones; Markus Engstler
Journal:  Int Rev Cell Mol Biol       Date:  2009       Impact factor: 6.813

3.  High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome.

Authors:  Sam Alsford; Daniel J Turner; Samson O Obado; Alejandro Sanchez-Flores; Lucy Glover; Matthew Berriman; Christiane Hertz-Fowler; David Horn
Journal:  Genome Res       Date:  2011-03-01       Impact factor: 9.043

Review 4.  RNA interference in protozoan parasites: achievements and challenges.

Authors:  Nikolay G Kolev; Christian Tschudi; Elisabetta Ullu
Journal:  Eukaryot Cell       Date:  2011-07-15

5.  A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei.

Authors:  E Wirtz; S Leal; C Ochatt; G A Cross
Journal:  Mol Biochem Parasitol       Date:  1999-03-15       Impact factor: 1.759

Review 6.  State of the art in African trypanosome drug discovery.

Authors:  Robert T Jacobs; Bakela Nare; Margaret A Phillips
Journal:  Curr Top Med Chem       Date:  2011       Impact factor: 3.295

7.  N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.

Authors:  Julie A Frearson; Stephen Brand; Stuart P McElroy; Laura A T Cleghorn; Ondrej Smid; Laste Stojanovski; Helen P Price; M Lucia S Guther; Leah S Torrie; David A Robinson; Irene Hallyburton; Chidochangu P Mpamhanga; James A Brannigan; Anthony J Wilkinson; Michael Hodgkinson; Raymond Hui; Wei Qiu; Olawale G Raimi; Daan M F van Aalten; Ruth Brenk; Ian H Gilbert; Kevin D Read; Alan H Fairlamb; Michael A J Ferguson; Deborah F Smith; Paul G Wyatt
Journal:  Nature       Date:  2010-04-01       Impact factor: 49.962

8.  A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes.

Authors:  Shane R Wilkinson; Martin C Taylor; David Horn; John M Kelly; Ian Cheeseman
Journal:  Proc Natl Acad Sci U S A       Date:  2008-03-26       Impact factor: 11.205

9.  High-throughput decoding of antitrypanosomal drug efficacy and resistance.

Authors:  Sam Alsford; Sabine Eckert; Nicola Baker; Lucy Glover; Alejandro Sanchez-Flores; Ka Fai Leung; Daniel J Turner; Mark C Field; Matthew Berriman; David Horn
Journal:  Nature       Date:  2012-01-25       Impact factor: 49.962

10.  Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods.

Authors:  Susan Wyllie; Sandra L Oza; Stephen Patterson; Daniel Spinks; Stephen Thompson; Alan H Fairlamb
Journal:  Mol Microbiol       Date:  2009-06-24       Impact factor: 3.501
View more
  4 in total

1.  Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity.

Authors:  Ornella Di Pietro; Esther Vicente-García; Martin C Taylor; Diana Berenguer; Elisabet Viayna; Anna Lanzoni; Irene Sola; Helena Sayago; Cristina Riera; Roser Fisa; M Victòria Clos; Belén Pérez; John M Kelly; Rodolfo Lavilla; Diego Muñoz-Torrero
Journal:  Eur J Med Chem       Date:  2015-10-19       Impact factor: 6.514

2.  The Role of Folate Transport in Antifolate Drug Action in Trypanosoma brucei.

Authors:  Simon Dewar; Natasha Sienkiewicz; Han B Ong; Richard J Wall; David Horn; Alan H Fairlamb
Journal:  J Biol Chem       Date:  2016-10-04       Impact factor: 5.157

Review 3.  Experimental Strategies to Explore Drug Action and Resistance in Kinetoplastid Parasites.

Authors:  Magali Van den Kerkhof; Yann G-J Sterckx; Philippe Leprohon; Louis Maes; Guy Caljon
Journal:  Microorganisms       Date:  2020-06-24

4.  Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents.

Authors:  Irene Sola; Albert Artigas; Martin C Taylor; F Javier Pérez-Areales; Elisabet Viayna; M Victòria Clos; Belén Pérez; Colin W Wright; John M Kelly; Diego Muñoz-Torrero
Journal:  Bioorg Med Chem       Date:  2016-08-22       Impact factor: 3.641
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.