Reinhard Dummer1, Keith T Flaherty. 1. Department of Dermatology, University Hospital Zurich, Zurich, Switzerland. reinhard.dummer@usz.ch
Abstract
PURPOSE OF REVIEW: After years of therapeutic approaches with limited effects in metastatic melanoma, new inhibitors of serine-threonine and tyrosine kinases have demonstrated impressive clinical efficacy and improved survival. RECENT FINDINGS: This review explains the molecular background for the development of specific kinase inhibitors and briefly summarizes their clinical impact on advanced melanoma. SUMMARY: Despite robust early clinical efficacy, the antiproliferative effect of these kinase inhibitors is limited. The resistance mechanisms are explored currently and will help to identify new targets for melanoma therapy.
PURPOSE OF REVIEW: After years of therapeutic approaches with limited effects in metastatic melanoma, new inhibitors of serine-threonine and tyrosine kinases have demonstrated impressive clinical efficacy and improved survival. RECENT FINDINGS: This review explains the molecular background for the development of specific kinase inhibitors and briefly summarizes their clinical impact on advanced melanoma. SUMMARY: Despite robust early clinical efficacy, the antiproliferative effect of these kinase inhibitors is limited. The resistance mechanisms are explored currently and will help to identify new targets for melanoma therapy.
Authors: Vaibhav Mundra; Yang Peng; Virender Kumar; Wei Li; Duane D Miller; Ram I Mahato Journal: Drug Deliv Transl Res Date: 2015-06 Impact factor: 4.617
Authors: Niki Karachaliou; Sara Pilotto; Cristina Teixidó; Santiago Viteri; María González-Cao; Aldo Riso; Daniela Morales-Espinosa; Miguel Angel Molina; Imane Chaib; Mariacarmela Santarpia; Eduardo Richardet; Emilio Bria; Rafael Rosell Journal: Ann Transl Med Date: 2015-10