Literature DB >> 22945358

Microenvironment-mediated resistance to anticancer therapies.

Oakley C Olson1, Johanna A Joyce.   

Abstract

Resistance to molecularly targeted therapies can result from genomic alterations in the tumor cells that reactivate oncogenic signaling. Less is known of tumor cell-extrinsic mechanisms of resistance to targeted therapies. Two recent studies have identified HGF as a soluble factor capable of mediating resistance to BRAF and HER2 inhibitors in a paracrine manner. These new findings suggest an important role for the tumor microenvironment in mediating resistance to molecularly targeted therapies.

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Year:  2012        PMID： 22945358      PMCID： PMC3567818          DOI： 10.1038/cr.2012.123

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  17 in total

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2.  A CXCL1 paracrine network links cancer chemoresistance and metastasis.

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Review 5.  Tumor and stromal pathways mediating refractoriness/resistance to anti-angiogenic therapies.

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  14 in total

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4.  Prognostic value of the ratio of maximum to minimum diameter of primary tumor in metastatic clear cell renal cell carcinoma.

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Review 5.  The Challenges of Modeling Drug Resistance to Antiangiogenic Therapy.

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6.  Inflammation and uPAR-Expression in Colorectal Liver Metastases in Relation to Growth Pattern and Neo-adjuvant Therapy.

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7.  Changes in the Secretory Profile of NSCLC-Associated Fibroblasts after Ablative Radiotherapy: Potential Impact on Angiogenesis and Tumor Growth.

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Review 8.  Mapping Mammary Tumor Traits in the Rat.

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Journal:  Oncogene       Date:  2018-01-25       Impact factor: 9.867
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