| Literature DB >> 22314498 |
Irina V Nesterova1, Mateusz L Hupert, Malgorzata A Witek, Steven A Soper.
Abstract
With the advent of next-generation sequencing (NGS) systems and the associated high throughput they afford, the input to these machines requires manageable lengths of fragments (~1000 bp) produced from chromosomal DNAs. Therefore, it is critical to develop devices that can shear DNA in a controlled fashion. We report a polymer-based microfluidic device that establishes an efficient and inexpensive platform with performance comparable to a commercially available bench-top system.Entities:
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Year: 2012 PMID： 22314498 DOI： 10.1039/c2lc21122j
Source DB: PubMed Journal: Lab Chip ISSN： 1473-0189 Impact factor: 6.799