Literature DB >> 22312712

Cytotoxic cembranoids from the Red Sea soft coral Sarcophyton glaucum.

Mohamed-Elamir F Hegazy1, Ahmed A El-Beih, Alaa Y Moustafa, Abdelhamed A Hamdy, Montaser A Alhammady, Rehab M Selim, Mohamed Abdel-Rehim, Paul W Paré.   

Abstract

One new cembrane diterpene, 2R,7R,8R-dihydroxydeepoxysarcophine (1), together with three known compounds, 7alpha,8beta-dihydroxydeepoxysarcophine (2), 7beta-acetoxy-8alpha-hydroxydeepoxysarcophine (3), and sarcophine (4), have been isolated from the Red Sea soft coral Sarcophyton glaucum. Their structures were determined using 1D and 2D NMR spectroscopy. 7beta-Acetoxy-8alpha-hydroxydeepoxysarcophine (3) exhibits cytotoxic activity against HepG2, HCT-116, and HeLa cells with IC50 values of 3.6, 2.3, and 6.7 microg/mL, respectively.

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Year:  2011        PMID： 22312712

Source DB:  PubMed          Journal:  Nat Prod Commun        ISSN： 1555-9475            Impact factor:   0.986


  8 in total

Review 1.  Molecular architecture and biomedical leads of terpenes from red sea marine invertebrates.

Authors:  Mohamed Elamir F Hegazy; Tarik A Mohamed; Montaser A Alhammady; Alaa M Shaheen; Eman H Reda; Abdelsamed I Elshamy; Mina Aziz; Paul W Paré
Journal:  Mar Drugs       Date:  2015-05-20       Impact factor: 5.118

2.  Cembrene Diterpenoids with Ether Linkages from Sarcophyton ehrenbergi: An Anti-Proliferation and Molecular-Docking Assessment.

Authors:  Mohamed-Elamir F Hegazy; Abdelsamed I Elshamy; Tarik A Mohamed; Ahmed R Hamed; Mahmoud A A Ibrahim; Shinji Ohta; Paul W Paré
Journal:  Mar Drugs       Date:  2017-06-21       Impact factor: 5.118

3.  Inducing Apoptosis of Cancer Cells Using Sea Pen Virgularia gustaviana Extract Which is Comparable to Cembrane Diterpene Sarcophine.

Authors:  Sharareh Sharifi; Pargol Ghavam Mostafavi; Ali Mashinchian Moradi; Mohammad Hadi Givianrad; Hassan Niknejad
Journal:  Iran J Pharm Res       Date:  2018       Impact factor: 1.696

Review 4.  Chemical Diversity in Species Belonging to Soft Coral Genus Sacrophyton and Its Impact on Biological Activity: A Review.

Authors:  Yasmin A Elkhawas; Ahmed M Elissawy; Mohamed S Elnaggar; Nada M Mostafa; Eman M Kamal; Mokhtar M Bishr; Abdel Nasser B Singab; Osama M Salama
Journal:  Mar Drugs       Date:  2020-01-06       Impact factor: 5.118

Review 5.  Cytotoxic Compounds from Alcyoniidae: An Overview of the Last 30 Years.

Authors:  Federico Cerri; Francesco Saliu; Davide Maggioni; Simone Montano; Davide Seveso; Silvia Lavorano; Luca Zoia; Fabio Gosetti; Marina Lasagni; Marco Orlandi; Orazio Taglialatela-Scafati; Paolo Galli
Journal:  Mar Drugs       Date:  2022-02-11       Impact factor: 5.118

6.  Sarcoehrenbergilides D-F: cytotoxic cembrene diterpenoids from the soft coral Sarcophyton ehrenbergi.

Authors:  Mohamed-Elamir F Hegazy; Tarik A Mohamed; Abdelsamed I Elshamy; Ahmed R Hamed; Mahmoud A A Ibrahim; Shinji Ohta; Akemi Umeyama; Paul W Paré; Thomas Efferth
Journal:  RSC Adv       Date:  2019-08-29       Impact factor: 3.361

7.  Sarcophyolides B-E, new cembranoids from the soft coral Sarcophyton elegans.

Authors:  Zhifang Xi; Wei Bie; Wei Chen; Dong Liu; Leen van Ofwegen; Peter Proksch; Wenhan Lin
Journal:  Mar Drugs       Date:  2013-08-26       Impact factor: 5.118

8.  New terpenes from the Egyptian soft coral Sarcophyton ehrenbergi.

Authors:  Ahmed Elkhateeb; Ahmed A El-Beih; Amira M Gamal-Eldeen; Montaser A Alhammady; Shinji Ohta; Paul W Paré; Mohamed-Elamir F Hegazy
Journal:  Mar Drugs       Date:  2014-04-02       Impact factor: 5.118
  8 in total

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