Literature DB >> 22311122

Pannexin 1 forms an anion-selective channel.

Weihong Ma1, Vincent Compan, Wenxuan Zheng, Elizabeth Martin, R Alan North, Alexei Verkhratsky, Annmarie Surprenant.   

Abstract

Pannexin 1 (Panx1) is expressed in various mammalian tissues including the brain and immune cells. Here, we present evidence that Panx1 when expressed in mammalian cells, forms anion-selective channels, with a rank order of permeabilities: NO (3) (-)> I(-) > Br (-)> Cl (-) > F (-)>> aspartate (-)≈ glutamate (-)≈ gluconate(-). Single-channel Panx1-mediated currents have a unitary conductance around 68 pS. Our results show that Panx1 assembles into a membrane anion channel with a relatively low single-channel conductance.

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Year:  2012        PMID： 22311122     DOI： 10.1007/s00424-012-1077-z

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  30 in total

1.  Pannexin membrane channels are mechanosensitive conduits for ATP.

Authors:  Li Bao; Silviu Locovei; Gerhard Dahl
Journal:  FEBS Lett       Date:  2004-08-13       Impact factor: 4.124

2.  Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium.

Authors:  Silviu Locovei; Junjie Wang; Gerhard Dahl
Journal:  FEBS Lett       Date:  2005-12-12       Impact factor: 4.124

3.  The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste buds.

Authors:  Yi-Jen Huang; Yutaka Maruyama; Gennady Dvoryanchikov; Elizabeth Pereira; Nirupa Chaudhari; Stephen D Roper
Journal:  Proc Natl Acad Sci U S A       Date:  2007-03-26       Impact factor: 11.205

4.  Expression of gap junction channels in communication-incompetent cells after stable transfection with cDNA encoding connexin 32.

Authors:  B Eghbali; J A Kessler; D C Spray
Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205

5.  Anion selectivity in biological systems.

Authors:  E M Wright; J M Diamond
Journal:  Physiol Rev       Date:  1977-01       Impact factor: 37.312

Review 6.  Non-junction functions of pannexin-1 channels.

Authors:  Brian A MacVicar; Roger J Thompson
Journal:  Trends Neurosci       Date:  2009-12-18       Impact factor: 13.837

7.  Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis.

Authors:  Faraaz B Chekeni; Michael R Elliott; Joanna K Sandilos; Scott F Walk; Jason M Kinchen; Eduardo R Lazarowski; Allison J Armstrong; Silvia Penuela; Dale W Laird; Guy S Salvesen; Brant E Isakson; Douglas A Bayliss; Kodi S Ravichandran
Journal:  Nature       Date:  2010-10-14       Impact factor: 49.962

8.  Pannexins, a family of gap junction proteins expressed in brain.

Authors:  Roberto Bruzzone; Sheriar G Hormuzdi; Michael T Barbe; Anne Herb; Hannah Monyer
Journal:  Proc Natl Acad Sci U S A       Date:  2003-11-03       Impact factor: 11.205

9.  Pannexin 1 contributes to ATP release in airway epithelia.

Authors:  George A Ransford; Nevis Fregien; Feng Qiu; Gerhard Dahl; Gregory E Conner; Matthias Salathe
Journal:  Am J Respir Cell Mol Biol       Date:  2009-02-12       Impact factor: 6.914

10.  Lack of coupling between membrane stretching and pannexin-1 hemichannels.

Authors:  Juan P Reyes; Carmen Y Hernández-Carballo; Gabriela Pérez-Flores; Patricia Pérez-Cornejo; Jorge Arreola
Journal:  Biochem Biophys Res Commun       Date:  2009-01-14       Impact factor: 3.575
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  54 in total

Review 1.  Neurotransmitters and integration in neuronal-astroglial networks.

Authors:  Alexei Verkhratsky; José Julio Rodríguez; Vladimir Parpura
Journal:  Neurochem Res       Date:  2012-04-03       Impact factor: 3.996

2.  Is pannexin the pore associated with the P2X7 receptor?

Authors:  A V P Alberto; R X Faria; C G C Couto; L G B Ferreira; C A M Souza; P C N Teixeira; M M Fróes; L A Alves
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2013-05-09       Impact factor: 3.000

Review 3.  ATP release through pannexon channels.

Authors:  Gerhard Dahl
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2015-07-05       Impact factor: 6.237

Review 4.  Emerging concepts regarding pannexin 1 in the vasculature.

Authors:  Miranda E Good; Daniela Begandt; Leon J DeLalio; Alexander S Keller; Marie Billaud; Brant E Isakson
Journal:  Biochem Soc Trans       Date:  2015-06       Impact factor: 5.407

5.  Function without form: an ongoing search for maxi-anion channel proteins. Focus on "Maxi-anion channel and pannexin 1 hemichannel constitute separate pathways for swelling-induced ATP release in murine L929 fibrosarcoma cells".

Authors:  George R Dubyak
Journal:  Am J Physiol Cell Physiol       Date:  2012-08-29       Impact factor: 4.249

Review 6.  Intrinsic properties and regulation of Pannexin 1 channel.

Authors:  Yu-Hsin Chiu; Kodi S Ravichandran; Douglas A Bayliss
Journal:  Channels (Austin)       Date:  2014-01-13       Impact factor: 2.581

Review 7.  Physiology of Astroglia.

Authors:  Alexei Verkhratsky; Maiken Nedergaard
Journal:  Physiol Rev       Date:  2018-01-01       Impact factor: 37.312

Review 8.  Connexin hemichannel and pannexin channel electrophysiology: how do they differ?

Authors:  Dakshesh Patel; Xian Zhang; Richard D Veenstra
Journal:  FEBS Lett       Date:  2014-01-14       Impact factor: 4.124

Review 9.  The bizarre pharmacology of the ATP release channel pannexin1.

Authors:  Gerhard Dahl; Feng Qiu; Junjie Wang
Journal:  Neuropharmacology       Date:  2013-03-13       Impact factor: 5.250

Review 10.  Flufenamic acid as an ion channel modulator.

Authors:  Romain Guinamard; Christophe Simard; Christopher Del Negro
Journal:  Pharmacol Ther       Date:  2013-01-25       Impact factor: 12.310
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