A new enantioselective α-oxidation of aldehydes has been accomplished using TEMPO and a synergistic combination of copper and organic catalysis. Expanding upon recently reported mechanistic studies, these mild catalytic conditions provide stable aldehyde products bearing a wide array of electronically and sterically diverse substructures. The utility of these oxidized products is highlighted by subsequent derivatization to a variety of common chiral synthons, without loss in enantiopurity.
A new enantioselective α-oxidation of aldehydes has been accomplished using n class="Chemical">TEMPO and a synergistic combination of copper and organic catalysis. Expanding upon recently reported mechanistic studies, these mild catalytic conditions provide stable aldehyde products bearing a wide array of electronically and sterically diverse substructures. The utility of these oxidized products is highlighted by subsequent derivatization to a variety of common chiral synthons, without loss in enantiopurity.
Authors: Jeffrey F Van Humbeck; Scott P Simonovich; Robert R Knowles; David W C MacMillan Journal: J Am Chem Soc Date: 2010-07-28 Impact factor: 15.419
Authors: Manuel Peifer; Raphaëlle Berger; Valerie W Shurtleff; Jay C Conrad; David W C MacMillan Journal: J Am Chem Soc Date: 2014-04-09 Impact factor: 15.419