| Literature DB >> 22306650 |
Thorsten Thye1, Ellis Owusu-Dabo, Fredrik O Vannberg, Reinout van Crevel, James Curtis, Edhyana Sahiratmadja, Yanina Balabanova, Christa Ehmen, Birgit Muntau, Gerd Ruge, Jürgen Sievertsen, John Gyapong, Vladyslav Nikolayevskyy, Philip C Hill, Giorgio Sirugo, Francis Drobniewski, Esther van de Vosse, Melanie Newport, Bachti Alisjahbana, Sergey Nejentsev, Tom H M Ottenhoff, Adrian V S Hill, Rolf D Horstmann, Christian G Meyer.
Abstract
After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10(-9)). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10(-11).Entities:
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Year: 2012 PMID： 22306650 PMCID： PMC3427019 DOI： 10.1038/ng.1080
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330