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Literature DB >> 22306607

Autocrine/juxtaparacrine regulation of axon fasciculation by Slit-Robo signaling.

Alexander Jaworski¹, Marc Tessier-Lavigne.

Abstract

Axons travel to their targets in bundles or fascicles, but the molecules regulating fasciculation remain incompletely characterized. We found that Slit2 and its Robo receptors are expressed by motor axons, and that inactivation of Slit2 or Robo1 and Robo2 in mice caused axons to defasciculate prematurely at muscle targets. In vitro, Slit2 secreted by motoneurons regulated fasciculation through Robo1 and Robo2. These results support the idea that Slit2 promotes axon fasciculation via an autocrine and/or juxtaparacrine mechanism.

Entities: Disease Gene Species

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Year: 2012 PMID： 22306607 DOI： 10.1038/nn.3037

Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884

14 in total

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Authors: Wenlin Yuan; Yi Rao; Randal P Babiuk; John J Greer; Jane Y Wu; David M Ornitz
Journal: Proc Natl Acad Sci U S A Date: 2003-04-17 Impact factor: 11.205

6. Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance.

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10. Genetic analysis of Fasciclin II in Drosophila: defasciculation, refasciculation, and altered fasciculation.

Authors: D M Lin; R D Fetter; C Kopczynski; G Grenningloh; C S Goodman
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43 in total

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4. Muscle Yap Is a Regulator of Neuromuscular Junction Formation and Regeneration.

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Journal: J Neurosci Date: 2017-02-17 Impact factor: 6.167

5. Slit and Semaphorin signaling governed by Islet transcription factors positions motor neuron somata within the neural tube.

Authors: Hojae Lee; Minkyung Kim; Namhee Kim; Todd Macfarlan; Samuel L Pfaff; Grant S Mastick; Mi-Ryoung Song
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10. Comparative Analysis of the Expression of Chondroitin Sulfate Subtypes and Their Inhibitory Effect on Axonal Growth in the Embryonic, Adult, and Injured Rat Brains.

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