Literature DB >> 22306342

Role of epigenetic aberrations in the development and progression of human hepatocellular carcinoma.

Igor P Pogribny1, Ivan Rusyn.   

Abstract

Hepatocellular carcinoma (HCC) is one of the most lethal and prevalent cancers in humans. The molecular mechanisms leading to the development of HCC are extremely complicated and consist of prominent genetic, genomic, and epigenetic alterations. This review summarizes the current knowledge of the role of epigenetic aberrations, including changes in DNA methylation, histone modifications, and expression of microRNAs in the pathogenesis of HCC. It also emphasizes that identification of the underlying epigenetic alterations that drive cell transformation and promote development and progression of HCC is crucially important for understanding mechanisms of hepatocarcinogenesis, its detection, therapeutic intervention, and prevention. Published by Elsevier Ireland Ltd.

Entities:  

Keywords:  DNA methylation; Hepatocellular carcinoma; Histone modifications; MicroRNAs

Mesh：

Substances：

Year:  2012        PMID： 22306342      PMCID： PMC3971756          DOI： 10.1016/j.canlet.2012.01.038

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  173 in total

1.  Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis.

Authors:  Y Saito; Y Kanai; M Sakamoto; H Saito; H Ishii; S Hirohashi
Journal:  Hepatology       Date:  2001-03       Impact factor: 17.425

Review 2.  The history of cancer epigenetics.

Authors:  Andrew P Feinberg; Benjamin Tycko
Journal:  Nat Rev Cancer       Date:  2004-02       Impact factor: 60.716

3.  Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis.

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Journal:  Proc Natl Acad Sci U S A       Date:  2005-09-08       Impact factor: 11.205

4.  Hypomethylation of the hsa-miR-191 locus causes high expression of hsa-mir-191 and promotes the epithelial-to-mesenchymal transition in hepatocellular carcinoma.

Authors:  Yinghua He; Ying Cui; Wei Wang; Jun Gu; Shicheng Guo; Kelong Ma; Xiaoying Luo
Journal:  Neoplasia       Date:  2011-09       Impact factor: 5.715

Review 5.  Epidemiology, risk factors and surveillance of hepatocellular carcinoma.

Authors:  G Cabibbo; A Craxì
Journal:  Eur Rev Med Pharmacol Sci       Date:  2010-04       Impact factor: 3.507

6.  Frequent epigenetic inactivation of spleen tyrosine kinase gene in human hepatocellular carcinoma.

Authors:  Yunfei Yuan; Jianping Wang; Jinqing Li; Li Wang; Meixiang Li; Zuli Yang; Changqing Zhang; Jia Le Dai
Journal:  Clin Cancer Res       Date:  2006-11-15       Impact factor: 12.531

7.  Methyl groups in carcinogenesis: effects on DNA methylation and gene expression.

Authors:  E Wainfan; L A Poirier
Journal:  Cancer Res       Date:  1992-04-01       Impact factor: 12.701

8.  Mammalian microRNAs predominantly act to decrease target mRNA levels.

Authors:  Huili Guo; Nicholas T Ingolia; Jonathan S Weissman; David P Bartel
Journal:  Nature       Date:  2010-08-12       Impact factor: 49.962

9.  Elevated expression of the miR-17-92 polycistron and miR-21 in hepadnavirus-associated hepatocellular carcinoma contributes to the malignant phenotype.

Authors:  Erin Connolly; Margherita Melegari; Pablo Landgraf; Tatyana Tchaikovskaya; Bud C Tennant; Betty L Slagle; Leslie E Rogler; Mihaela Zavolan; Thomas Tuschl; Charles E Rogler
Journal:  Am J Pathol       Date:  2008-08-07       Impact factor: 4.307

10.  Global DNA hypomethylation in liver cancer cases and controls: a phase I preclinical biomarker development study.

Authors:  Rafael Guerrero-Preston; Regina M Santella; Adolfo Blanco; Manisha Desai; Maria Berdasco; Mario Fraga
Journal:  Epigenetics       Date:  2007-10-29       Impact factor: 4.528
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  77 in total

1.  Detecting hepatocellular carcinoma in blood.

Authors:  Lulu Hu; Chuan He
Journal:  Cell Res       Date:  2015-11-24       Impact factor: 25.617

Review 2.  Molecular Pathogenesis of Liver Cancer.

Authors:  Mehmet Ozturk; Tugce Batur; Umut Ekin; Aybike Erdogan; Evin İscan; Umur Keles; Ozden Oz; Cigdem Ozen
Journal:  J Gastrointest Cancer       Date:  2017-09

3.  Epigenetic silencing of microRNA-373 to epithelial-mesenchymal transition in non-small cell lung cancer through IRAK2 and LAMP1 axes.

Authors:  Hyang Sook Seol; Yoshimitsu Akiyama; Shu Shimada; Hee Jin Lee; Tae Im Kim; Sung Min Chun; Shree Ram Singh; Se Jin Jang
Journal:  Cancer Lett       Date:  2014-07-22       Impact factor: 8.679

4.  Genetic and epigenetic determinants of inter-individual variability in responses to toxicants.

Authors:  Lauren Lewis; Gregory E Crawford; Terrence S Furey; Ivan Rusyn
Journal:  Curr Opin Toxicol       Date:  2017-09-12

5.  The mouse HP1 proteins are essential for preventing liver tumorigenesis.

Authors:  Nehmé Saksouk; Shefqet Hajdari; Yannick Perez; Marine Pratlong; Célia Barrachina; Céline Graber; Damien Grégoire; Aliki Zavoriti; Amélie Sarrazin; Nelly Pirot; Jean-Yohan Noël; Lakhdar Khellaf; Eric Fabbrizio; Eric Julien; Florence M Cammas
Journal:  Oncogene       Date:  2020-02-04       Impact factor: 9.867

Review 6.  Hepatocellular carcinoma and the risk of occupational exposure.

Authors:  Venerando Rapisarda; Carla Loreto; Michele Malaguarnera; Annalisa Ardiri; Maria Proiti; Giuseppe Rigano; Evelise Frazzetto; Maria Irene Ruggeri; Giulia Malaguarnera; Nicoletta Bertino; Mariano Malaguarnera; Vito Emanuele Catania; Isidoro Di Carlo; Adriana Toro; Emanuele Bertino; Dario Mangano; Gaetano Bertino
Journal:  World J Hepatol       Date:  2016-05-08

7.  Epigenetic silencing of PRSS3 provides growth and metastasis advantage for human hepatocellular carcinoma.

Authors:  Bonan Lin; Xiaomeng Zhou; Shuye Lin; Xiaoyue Wang; Meiying Zhang; Baoping Cao; Yan Dong; Shuai Yang; Ji Ming Wang; Mingzhou Guo; Jiaqiang Huang
Journal:  J Mol Med (Berl)       Date:  2017-08-26       Impact factor: 4.599

8.  The association between polymorphism of P53 Codon72 Arg/Pro and hepatocellular carcinoma susceptibility: evidence from a meta-analysis of 15 studies with 3,704 cases.

Authors:  Surong Hu; Lianying Zhao; Jingting Yang; Miao Hu
Journal:  Tumour Biol       Date:  2013-12-11

Review 9.  Choline's role in maintaining liver function: new evidence for epigenetic mechanisms.

Authors:  Mihai G Mehedint; Steven H Zeisel
Journal:  Curr Opin Clin Nutr Metab Care       Date:  2013-05       Impact factor: 4.294

Review 10.  Hepatitis B virus X protein-induced aberrant epigenetic modifications contributing to human hepatocellular carcinoma pathogenesis.

Authors:  Yi Tian; Weibing Yang; Jianxun Song; Yuzhang Wu; Bing Ni
Journal:  Mol Cell Biol       Date:  2013-05-28       Impact factor: 4.272
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