| Literature DB >> 27168870 |
Venerando Rapisarda1, Carla Loreto1, Michele Malaguarnera1, Annalisa Ardiri1, Maria Proiti1, Giuseppe Rigano1, Evelise Frazzetto1, Maria Irene Ruggeri1, Giulia Malaguarnera1, Nicoletta Bertino1, Mariano Malaguarnera1, Vito Emanuele Catania1, Isidoro Di Carlo1, Adriana Toro1, Emanuele Bertino1, Dario Mangano1, Gaetano Bertino1.
Abstract
Hepatocellular carcinoma (HCC) is the most common type of liver cancer. The main risk factors for HCC are alcoholism, hepatitis B virus, hepatitis C virus, nonalcoholic steatohepatitis, obesity, type 2 diabetes, cirrhosis, aflatoxin, hemochromatosis, Wilson's disease and hemophilia. Occupational exposure to chemicals is another risk factor for HCC. Often the relationship between occupational risk and HCC is unclear and the reports are fragmented and inconsistent. This review aims to summarize the current knowledge regarding the association of infective and non-infective occupational risk exposure and HCC in order to encourage further research and draw attention to this global occupational public health problem.Entities:
Keywords: Arsenic; Autophagy; Cadmium; Chemical agents; Epigenetic events; Hepatitis B virus; Hepatitis C virus; Hepatocellular carcinoma; Mitophagy; Occupational exposure
Year: 2016 PMID: 27168870 PMCID: PMC4858622 DOI: 10.4254/wjh.v8.i13.573
Source DB: PubMed Journal: World J Hepatol