| Literature DB >> 22305607 |
Vera Bonardi1, Karen Cherkis, Marc T Nishimura, Jeffery L Dangl.
Abstract
The nucleotide-binding domain leucine-rich repeat proteins (NLRs) represent the major class of intracellular innate immune receptors in plants and animals. Understanding their functions is a major challenge in immunology. This review highlights recent efforts toward elucidating NLR functions in human and plants. We compare unconventional aspects of NLR proteins across the two kingdoms. We review recent advances describing P-loop independent activation, nuclear-cytoplasmic trafficking, oligomerization and multimerization requirements for signaling, and for expanded functions beyond pathogen recognition by several NLR proteins. Copyright ÂEntities:
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Year: 2012 PMID： 22305607 PMCID： PMC3482489 DOI： 10.1016/j.coi.2011.12.006
Source DB: PubMed Journal: Curr Opin Immunol ISSN： 0952-7915 Impact factor: 7.486