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Literature DB >> 22305561

The potential of stem cells as an in vitro source of red blood cells for transfusion.

Anna Rita Migliaccio¹, Carolyn Whitsett, Thalia Papayannopoulou, Michel Sadelain.

Abstract

Recent advances have increased excitement about the potential for therapeutic production of red blood cells (RBCs) in vitro. However, generation of RBCs in the large numbers required for transfusion remains a significant challenge. In this article, we summarize recent progress in producing RBCs from various cell sources, and discuss the hurdles that remain for translation into the clinical arena.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Year: 2012 PMID： 22305561 PMCID： PMC3676433 DOI： 10.1016/j.stem.2012.01.001

Source DB: PubMed Journal: Cell Stem Cell ISSN： 1875-9777 Impact factor: 24.633

21 in total

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Authors: Shi-Jiang Lu; Qiang Feng; Jennifer S Park; Loyda Vida; Bao-Shiang Lee; Michael Strausbauch; Peter J Wettstein; George R Honig; Robert Lanza
Journal: Blood Date: 2008-08-19 Impact factor: 22.113

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10. Multicolor staining of globin subtypes reveals impaired globin switching during erythropoiesis in human pluripotent stem cells.

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