BACKGROUND AND PURPOSE: Temporal lobe epilepsy (TLE) with nontumoral amygdala enlargement (AE) has been reported to be a possible subtype of TLE without hippocampal sclerosis (HS). The purpose of this study was to clarify morphologic and functional characteristics of TLE with AE (TLE + AE). METHODS: We evaluated gray matter volume and cerebral glucose hypometabolism using magnetic resonance imaging (MRI) voxel-based morphometry (VBM) and voxel-based statistical analysis of [(18) F]-fluorodeoxyglucose positron emission tomography (FDG-PET) images in 9 patients with TLE + AE as compared with controls. For VBM analysis, we recruited 30 age- and sex-matched healthy volunteers as controls. For the comparison of FDG-PET analysis, 9 patients with definite mesial TLE with HS (MTLE + HS), and 16 age- and sex-matched healthy controls were recruited. RESULTS: In patients with TLE + AE, a significant increase in gray matter volume was found only in the affected amygdala, and no significant decrease in gray matter volume was detected. In addition, significant glucose hypometabolism was observed in the affected amygdala, whereas significant glucose hypometabolism in the hippocampus, a prominent feature of definite MTLE+HS, was not observed. CONCLUSIONS: TLE + AE is different from MTLE + HS from morphologic and functional points of view, and the enlarged amygdala per se is potentially an epileptic focus in patients with partial epilepsy.
BACKGROUND AND PURPOSE:Temporal lobe epilepsy (TLE) with nontumoral amygdala enlargement (AE) has been reported to be a possible subtype of TLE without hippocampal sclerosis (HS). The purpose of this study was to clarify morphologic and functional characteristics of TLE with AE (TLE + AE). METHODS: We evaluated gray matter volume and cerebral glucose hypometabolism using magnetic resonance imaging (MRI) voxel-based morphometry (VBM) and voxel-based statistical analysis of [(18) F]-fluorodeoxyglucose positron emission tomography (FDG-PET) images in 9 patients with TLE + AE as compared with controls. For VBM analysis, we recruited 30 age- and sex-matched healthy volunteers as controls. For the comparison of FDG-PET analysis, 9 patients with definite mesial TLE with HS (MTLE + HS), and 16 age- and sex-matched healthy controls were recruited. RESULTS: In patients with TLE + AE, a significant increase in gray matter volume was found only in the affected amygdala, and no significant decrease in gray matter volume was detected. In addition, significant glucose hypometabolism was observed in the affected amygdala, whereas significant glucose hypometabolism in the hippocampus, a prominent feature of definite MTLE+HS, was not observed. CONCLUSIONS:TLE + AE is different from MTLE + HS from morphologic and functional points of view, and the enlarged amygdala per se is potentially an epileptic focus in patients with partial epilepsy.
Authors: Anny Reyes; Thomas Thesen; Ruben Kuzniecky; Orrin Devinsky; Carrie R McDonald; Graeme D Jackson; David N Vaughan; Karen Blackmon Journal: Epilepsy Res Date: 2017-03-02 Impact factor: 3.045
Authors: Martin J Brodie; Frank Besag; Alan B Ettinger; Marco Mula; Gabriella Gobbi; Stefano Comai; Albert P Aldenkamp; Bernhard J Steinhoff Journal: Pharmacol Rev Date: 2016-07 Impact factor: 25.468
Authors: Christopher D Whelan; Andre Altmann; Juan A Botía; Neda Jahanshad; Derrek P Hibar; Julie Absil; Saud Alhusaini; Marina K M Alvim; Pia Auvinen; Emanuele Bartolini; Felipe P G Bergo; Tauana Bernardes; Karen Blackmon; Barbara Braga; Maria Eugenia Caligiuri; Anna Calvo; Sarah J Carr; Jian Chen; Shuai Chen; Andrea Cherubini; Philippe David; Martin Domin; Sonya Foley; Wendy França; Gerrit Haaker; Dmitry Isaev; Simon S Keller; Raviteja Kotikalapudi; Magdalena A Kowalczyk; Ruben Kuzniecky; Soenke Langner; Matteo Lenge; Kelly M Leyden; Min Liu; Richard Q Loi; Pascal Martin; Mario Mascalchi; Marcia E Morita; Jose C Pariente; Raul Rodríguez-Cruces; Christian Rummel; Taavi Saavalainen; Mira K Semmelroch; Mariasavina Severino; Rhys H Thomas; Manuela Tondelli; Domenico Tortora; Anna Elisabetta Vaudano; Lucy Vivash; Felix von Podewils; Jan Wagner; Bernd Weber; Yi Yao; Clarissa L Yasuda; Guohao Zhang; Nuria Bargalló; Benjamin Bender; Neda Bernasconi; Andrea Bernasconi; Boris C Bernhardt; Ingmar Blümcke; Chad Carlson; Gianpiero L Cavalleri; Fernando Cendes; Luis Concha; Norman Delanty; Chantal Depondt; Orrin Devinsky; Colin P Doherty; Niels K Focke; Antonio Gambardella; Renzo Guerrini; Khalid Hamandi; Graeme D Jackson; Reetta Kälviäinen; Peter Kochunov; Patrick Kwan; Angelo Labate; Carrie R McDonald; Stefano Meletti; Terence J O'Brien; Sebastien Ourselin; Mark P Richardson; Pasquale Striano; Thomas Thesen; Roland Wiest; Junsong Zhang; Annamaria Vezzani; Mina Ryten; Paul M Thompson; Sanjay M Sisodiya Journal: Brain Date: 2018-02-01 Impact factor: 13.501