BACKGROUND: To measure choroidal thickness in normal eyes and in patients with normal-tension glaucoma using enhanced depth imaging optical coherence tomography and evaluate the association between choroidal thickness and progression of visual field damage. DESIGN: Cross-sectional comparative study. PARTICIPANTS: A total of 62 eyes of 62 normal subjects and 45 eyes of 45 normal-tension glaucoma patients were examined. METHODS: The choroid was measured at the fovea and 3 mm nasal and temporal from the fovea. In the separate study, both eyes of the patients with normal-tension glaucoma were included in the analyses. Visual fields were measured with automated perimetry. Changes in mean deviation per year (dB/year), that is, mean deviation slope, were calculated. MAIN OUTCOME MEASURES: Difference in the choroidal thickness between the normal subjects and the patients with normal-tension glaucoma. The relationship between mean deviation slope and the choroidal thickness in eyes with normal-tension glaucoma was analysed. RESULTS: Compared with normal subjects, the choroidal thickness was significantly thinner in eyes with normal-tension glaucoma at 3 mm nasal from the fovea (P = 0.02). There was a significant correlation between the choroidal thickness at 3 mm nasal from the fovea and the mean deviation slope (Pearson's r = 0.413; P < 0.001). CONCLUSION: The decrease in the thickness of the choroid at 3 mm nasal from the fovea in eyes with normal-tension glaucoma may be associated with progressive visual field loss. Thus, choroidal abnormalities may play a role in the pathogenesis of normal-tension glaucoma.
BACKGROUND: To measure choroidal thickness in normal eyes and in patients with normal-tension glaucoma using enhanced depth imaging optical coherence tomography and evaluate the association between choroidal thickness and progression of visual field damage. DESIGN: Cross-sectional comparative study. PARTICIPANTS: A total of 62 eyes of 62 normal subjects and 45 eyes of 45 normal-tension glaucomapatients were examined. METHODS: The choroid was measured at the fovea and 3 mm nasal and temporal from the fovea. In the separate study, both eyes of the patients with normal-tension glaucoma were included in the analyses. Visual fields were measured with automated perimetry. Changes in mean deviation per year (dB/year), that is, mean deviation slope, were calculated. MAIN OUTCOME MEASURES: Difference in the choroidal thickness between the normal subjects and the patients with normal-tension glaucoma. The relationship between mean deviation slope and the choroidal thickness in eyes with normal-tension glaucoma was analysed. RESULTS: Compared with normal subjects, the choroidal thickness was significantly thinner in eyes with normal-tension glaucoma at 3 mm nasal from the fovea (P = 0.02). There was a significant correlation between the choroidal thickness at 3 mm nasal from the fovea and the mean deviation slope (Pearson's r = 0.413; P < 0.001). CONCLUSION: The decrease in the thickness of the choroid at 3 mm nasal from the fovea in eyes with normal-tension glaucoma may be associated with progressive visual field loss. Thus, choroidal abnormalities may play a role in the pathogenesis of normal-tension glaucoma.
Authors: Kaweh Mansouri; Felipe A Medeiros; Andrew J Tatham; Nicholas Marchase; Robert N Weinreb Journal: Am J Ophthalmol Date: 2014-02-14 Impact factor: 5.258
Authors: Craig Wilde; Ali Poostchi; Rajesh Narendran; Hamish K MacNab; Jonathan G Hillman; Phillip Alexander; Winfried M Amoaku; Stephen A Vernon Journal: Eye (Lond) Date: 2018-11-01 Impact factor: 3.775
Authors: Chunwei Zhang; Andrew J Tatham; Felipe A Medeiros; Linda M Zangwill; Zhiyong Yang; Robert N Weinreb Journal: PLoS One Date: 2014-10-08 Impact factor: 3.240
Authors: Ya Xing Wang; Liang Xu; Lei Shao; Ya Qin Zhang; Hua Yang; Jin Da Wang; Jost B Jonas; Wen Bin Wei Journal: PLoS One Date: 2014-09-11 Impact factor: 3.240