Literature DB >> 2229937

Biomarkers of aging: do we know what to look for?

A D Mooradian1.   

Abstract

The identification of specific biomarkers of aging would be an important milestone in gerontologic research. In this communication, the goals of identifying biomarkers of aging are summarized and some criteria for defining biomarkers are suggested. An age-related alteration in a biological parameter is not necessarily a biomarker of aging. None of the previously observed age-related changes satisfies all the criteria. Potential biomarkers that are applicable to human aging include in vitro proliferative capacity of fibroblasts, glycation of collagen, and DNA unwinding rate. Future research should focus on identifying age-related changes that are not merely expressions of aging, but also have some causal link to aging.

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Year:  1990        PMID： 2229937     DOI： 10.1093/geronj/45.6.b183

Source DB:  PubMed          Journal:  J Gerontol        ISSN： 0022-1422


  7 in total

1.  Select aging biomarkers based on telomere length and chronological age to build a biological age equation.

Authors:  Wei-Guang Zhang; Shu-Ying Zhu; Xiao-Juan Bai; De-Long Zhao; Shi-Min Jian; Juan Li; Zuo-Xiang Li; Bo Fu; Guang-Yan Cai; Xue-Feng Sun; Xiang-Mei Chen
Journal:  Age (Dordr)       Date:  2014-06

2.  Advanced glycation end-products as markers of aging and longevity in the long-lived Ansell's mole-rat (Fukomys anselli).

Authors:  Philip Dammann; David R Sell; Sabine Begall; Christopher Strauch; Vincent M Monnier
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2011-12-09       Impact factor: 6.053

3.  Retroviral gene expression as a possible biomarker of aging.

Authors:  Y Wada; M Tsukada; S Kamiyama; A Koizumi
Journal:  Int Arch Occup Environ Health       Date:  1993       Impact factor: 3.015

4.  Quantification of excision repair cross-complementing group 1 and survival in p16-negative squamous cell head and neck cancers.

Authors:  Ranee Mehra; Fang Zhu; Dong-Hua Yang; Kathy Q Cai; Joellen Weaver; Mahendra K Singh; Anna S Nikonova; Erica A Golemis; Douglas B Flieder; Harry S Cooper; Miriam Lango; John A Ridge; Barbara Burtness
Journal:  Clin Cancer Res       Date:  2013-10-02       Impact factor: 12.531

5.  Is 60 the New 50? Examining Changes in Biological Age Over the Past Two Decades.

Authors:  Morgan E Levine; Eileen M Crimmins
Journal:  Demography       Date:  2018-04

Review 6.  Common methods of biological age estimation.

Authors:  Linpei Jia; Weiguang Zhang; Xiangmei Chen
Journal:  Clin Interv Aging       Date:  2017-05-11       Impact factor: 4.458

7.  Biological age and tempos of aging in women over 60 in connection with their morphofunctional characteristics.

Authors:  Marina Negasheva; Natalia Lapshina; Rostislav Okushko; Elena Godina
Journal:  J Physiol Anthropol       Date:  2014-05-19       Impact factor: 2.867
  7 in total

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