PURPOSE: Although it is known that those patients who have developed colorectal cancer (CRC) are at a higher risk to develop metachronous adenoma or CRC, no study has been performed to analyze the relationship between the risk factors and the time course for the formation of postoperative adenoma using survival analysis. METHODS: One hundred seventy-six patients with CRC,who had received surgical resection, were endoscopically followed-up to detect the development of metachronous adenoma or adenocarcinoama. The association between the risk factors such as age, synchronous adenomas with index CRC or other clinicopathological variables and the formation of postoperative adenoma was assessed using the logrank test and the Cox proportional hazard model. RESULTS: Age over 60, synchronous lesions at the time of surgery for primary CRCs and presence of diabetes mellitus(DM) as the associated disease were positively related to the formation of postoperative adenoma. Among those patients with the three risk factors, only 27.8% remained adenoma-free during 5 years after operation, whereas in the group without any risk factor, it was 90.4%. CONCLUSIONS: From our data, age over 60, synchronous adenomas or CRCs and DM were the potential risk factors for the postoperative formation of adenoma or CRC, and they should be taken into consideration when defining the appropriate interval of postoperative colonoscopy.
PURPOSE: Although it is known that those patients who have developed colorectal cancer (CRC) are at a higher risk to develop metachronous adenoma or CRC, no study has been performed to analyze the relationship between the risk factors and the time course for the formation of postoperative adenoma using survival analysis. METHODS: One hundred seventy-six patients with CRC,who had received surgical resection, were endoscopically followed-up to detect the development of metachronous adenoma or adenocarcinoama. The association between the risk factors such as age, synchronous adenomas with index CRC or other clinicopathological variables and the formation of postoperative adenoma was assessed using the logrank test and the Cox proportional hazard model. RESULTS: Age over 60, synchronous lesions at the time of surgery for primary CRCs and presence of diabetes mellitus(DM) as the associated disease were positively related to the formation of postoperative adenoma. Among those patients with the three risk factors, only 27.8% remained adenoma-free during 5 years after operation, whereas in the group without any risk factor, it was 90.4%. CONCLUSIONS: From our data, age over 60, synchronous adenomas or CRCs and DM were the potential risk factors for the postoperative formation of adenoma or CRC, and they should be taken into consideration when defining the appropriate interval of postoperative colonoscopy.
Authors: R L Cali; R M Pitsch; A G Thorson; P Watson; P Tapia; G J Blatchford; M A Christensen Journal: Dis Colon Rectum Date: 1993-04 Impact factor: 4.585
Authors: Mazda Jenab; Elio Riboli; Rebecca J Cleveland; Teresa Norat; Sabina Rinaldi; Alexandra Nieters; Carine Biessy; Ann Tjønneland; Anja Olsen; Kim Overvad; Henning Grønbaek; Françoise Clavel-Chapelon; Marie-Christine Boutron-Ruault; Jakob Linseisen; Heiner Boeing; Tobias Pischon; Dimitrios Trichopoulos; Eleni Oikonomou; Antonia Trichopoulou; Salvatore Panico; Paolo Vineis; Franco Berrino; Rosario Tumino; Giovanna Masala; Petra H Peters; Carla H van Gils; H Bas Bueno-de-Mesquita; Marga C Ocké; Eiliv Lund; Michelle A Mendez; María José Tormo; Aurelio Barricarte; Carmen Martínez-García; Miren Dorronsoro; José Ramón Quirós; Göran Hallmans; Richard Palmqvist; Göran Berglund; Jonas Manjer; Timothy Key; Naomi E Allen; Sheila Bingham; Kay-Tee Khaw; Anne Cust; Rudolf Kaaks Journal: Int J Cancer Date: 2007-07-15 Impact factor: 7.396
Authors: Charles J Kahi; C Richard Boland; Jason A Dominitz; Francis M Giardiello; David A Johnson; Tonya Kaltenbach; David Lieberman; Theodore R Levin; Douglas J Robertson; Douglas K Rex Journal: Am J Gastroenterol Date: 2016-02-12 Impact factor: 10.864
Authors: Yuk Fai Lam; Wai Kay Seto; Teresa Tong; Ka Shing Cheung; Oswens Lo; Ivan Fn Hung; Wai Lun Law; Wai K Leung Journal: Intest Res Date: 2018-10-10