Literature DB >> 22293966

Estimating intestinal mucosal permeation of compounds using Caco-2 cell monolayers.

J Gao1, E D Hugger, M S Beck-Westermeyer, R T Borchardt.   

Abstract

Step-by-step protocols are provided in this unit for the measurement of apparent permeability coefficients of compounds using Caco-2 cell monolayers as an in vitro model of the intestinal mucosa. Procedures for culturing the cells and transmonolayer transport studies are also included. Critical issues for successfully estimating intestinal mucosal permeation of drugs are discussed. Step-by-step protocols are provided in this unit for the measurement of apparent permeability coefficients of compounds using.

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Year:  2001        PMID： 22293966     DOI： 10.1002/0471141755.ph0702s08

Source DB:  PubMed          Journal:  Curr Protoc Pharmacol        ISSN： 1934-8282


  5 in total

1.  In vitro models for studying trophoblast transcellular transport.

Authors:  Claudia J Bode; Hong Jin; Erik Rytting; Peter S Silverstein; Amber M Young; Kenneth L Audus
Journal:  Methods Mol Med       Date:  2006

2.  Development of a Clinically Relevant Dissolution Method for Metaxalone Immediate Release Formulations Based on an IVIVC Model.

Authors:  Lucija Vuletić; M Zahirul I Khan; Drago Špoljarić; Maja Radić; Biserka Cetina-Čižmek; Jelena Filipović-Grčić
Journal:  Pharm Res       Date:  2018-06-22       Impact factor: 4.200

3.  Characterization of the intestinal absorption of seven flavonoids from the flowers of Trollius chinensis using the Caco-2 cell monolayer model.

Authors:  Lijia Liu; Lina Guo; Can Zhao; Xiuwen Wu; Rufeng Wang; Chen Liu
Journal:  PLoS One       Date:  2015-03-19       Impact factor: 3.240

4.  The octanol/water distribution coefficients of ardipusilloside-I and its metabolites, and their permeation characteristics across Caco-2 cell monolayer.

Authors:  Wei-Yu Cao; Bin Feng; Li-Fei Cheng; Ying Wang; Ji Wang; Xiao-Juan Wang
Journal:  Chem Cent J       Date:  2016-05-05       Impact factor: 4.215

5.  Intestinal transportations of main chemical compositions of polygoni multiflori radix in caco-2 cell model.

Authors:  Jie Yu; Na Li; Pei Lin; Yunfei Li; Xiaojian Mao; Getuzhaori Bao; Wen Gu; Ronghua Zhao
Journal:  Evid Based Complement Alternat Med       Date:  2014-02-12       Impact factor: 2.629
  5 in total

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