Literature DB >> 22293554

(Mis)treating the pharmacogenetic incidentalome.

Isaac S Kohane1.   

Abstract

Genome-wide screening is anticipated to accelerate the development of personalized medicine by identifying and exploiting new associations between genomic variants and drug responses. However, this goal could be undermined if care is not taken to minimize the impact of pharmacogenomic associations that turn out to have narrower implications than suggested by initial studies.

Entities:  

Mesh:

Substances:

Year:  2012        PMID: 22293554     DOI: 10.1038/nrd3659

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN: 1474-1776            Impact factor:   84.694


  7 in total

1.  The incidentalome: a threat to genomic medicine.

Authors:  Isaac S Kohane; Daniel R Masys; Russ B Altman
Journal:  JAMA       Date:  2006-07-12       Impact factor: 56.272

2.  Medicine. Reestablishing the researcher-patient compact.

Authors:  Isaac S Kohane; Kenneth D Mandl; Patrick L Taylor; Ingrid A Holm; Daniel J Nigrin; Louis M Kunkel
Journal:  Science       Date:  2007-05-11       Impact factor: 47.728

Review 3.  CNVs of human genes and their implication in pharmacogenetics.

Authors:  I Johansson; M Ingelman-Sundberg
Journal:  Cytogenet Genome Res       Date:  2009-03-11       Impact factor: 1.636

Review 4.  Using electronic health records to drive discovery in disease genomics.

Authors:  Isaac S Kohane
Journal:  Nat Rev Genet       Date:  2011-05-18       Impact factor: 53.242

5.  Penetrance of 845G--> A (C282Y) HFE hereditary haemochromatosis mutation in the USA.

Authors:  Ernest Beutler; Vincent J Felitti; James A Koziol; Ngoc J Ho; Terri Gelbart
Journal:  Lancet       Date:  2002-01-19       Impact factor: 79.321

6.  The very low penetrance of cystic fibrosis for the R117H mutation: a reappraisal for genetic counselling and newborn screening.

Authors:  C Thauvin-Robinet; A Munck; F Huet; E Génin; G Bellis; E Gautier; M-P Audrézet; C Férec; G Lalau; M Des Georges; M Claustres; T Bienvenu; B Gérard; P Boisseau; F Cabet-Bey; D Feldmann; C Clavel; E Bieth; A Iron; B Simon-Bouy; C Costa; R Medina; J Leclerc; D Hubert; R Nové-Josserand; I Sermet-Gaudelus; G Rault; J Flori; S Leroy; N Wizla; G Bellon; A Haloun; S Perez-Martin; G d'Acremont; H Corvol; A Clément; E Houssin; C Binquet; C Bonithon-Kopp; C Alberti-Boulmé; M A Morris; L Faivre; M Goossens; M Roussey; E Girodon
Journal:  J Med Genet       Date:  2009-06-29       Impact factor: 6.318

7.  Follow-up of carriers of BRCA1 and BRCA2 variants of unknown significance: variant reclassification and surgical decisions.

Authors:  Mitzi L Murray; Felecia Cerrato; Robin L Bennett; Gail P Jarvik
Journal:  Genet Med       Date:  2011-12       Impact factor: 8.822

  7 in total
  6 in total

Review 1.  Pharmacogenetics in the evaluation of new drugs: a multiregional regulatory perspective.

Authors:  Marc Maliepaard; Charity Nofziger; Marisa Papaluca; Issam Zineh; Yoshiaki Uyama; Krishna Prasad; Christian Grimstein; Michael Pacanowski; Falk Ehmann; Silvia Dossena; Markus Paulmichl
Journal:  Nat Rev Drug Discov       Date:  2013-02       Impact factor: 84.694

2.  Personalized sequencing and the future of medicine: discovery, diagnosis and defeat of disease.

Authors:  Edward D Esplin; Ling Oei; Michael P Snyder
Journal:  Pharmacogenomics       Date:  2014-11       Impact factor: 2.533

Review 3.  Pharmacosynthetics: Reimagining the pharmacogenetic approach.

Authors:  Martilias S Farrell; Bryan L Roth
Journal:  Brain Res       Date:  2012-10-09       Impact factor: 3.252

4.  Incidental variants are critical for genomics.

Authors:  Leslie G Biesecker
Journal:  Am J Hum Genet       Date:  2013-05-02       Impact factor: 11.025

5.  Head-and-neck squamous cell carcinoma risk in smokers: no association detected between phenotype and AHR, CYP1A1, CYP1A2, or CYP1B1 genotype.

Authors:  Lucia F Jorge-Nebert; Ge Zhang; Keith M Wilson; Zhengwen Jiang; Randall Butler; Jack L Gluckman; Susan M Pinney; Daniel W Nebert
Journal:  Hum Genomics       Date:  2016-11-28       Impact factor: 4.639

6.  Pharmacogenomics in children: advantages and challenges of next generation sequencing applications.

Authors:  O M Vanakker; A De Paepe
Journal:  Int J Pediatr       Date:  2013-01-17
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.