Aruna V Vanikar1, Kamal V Kanodia, Rashmi D Patel, Kamlesh S Suthar, Himanshu V Patel, Manoj R Gumber, Hargovind L Trivedi. 1. Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, G. R. Doshi and K. M. Mehta Institute of Kidney Diseases & Research Centre (IKDRC)- Dr. H.L. Trivedi Institute of Transplantation Sciences (ITS), Civil Hospital Campus, Asarwa, Ahmedabad, 380016 Gujarat, India. vanikararuna@yahoo.com
Abstract
OBJECTIVE: To find out the incidence and natural history of IgMN in India. METHODS: Renal biopsies of children ≤12 y age of last 6 y were retrospectively evaluated. Their clinical and biochemical presentation were correlated. Patients with systemic diseases/disorders were excluded from the study. RESULTS: Immunoglobulin M nephropathy (IgMN) constituted 11.9% (n = 28) of 236 renal biopsies. Mean age was 10 y, predominant in boys (n = 24), most of the patients presented with proteinuria and edema. The most common associated histopathological finding was mesangial proliferative glomerulonephritis (MePGN) in 60.7% (n = 17) followed by minimal change disease (MCD) in 28.6% (n = 8) and focal segmental glomerulosclerosis (FSGS) in 10.7% (n = 3). In 85.7%, IgM appeared as the sole immunoglobulin deposit mainly in mesangial regions, followed by accompanied C3 in 3.6% (n = 1) and C1q + C3 in 10.7% (n = 3) biopsies. CONCLUSIONS: IgMN was observed in 11.9% biopsies with commonest morphology of MePGN followed by MCD and FSGS; proteinuria was bad prognosticator in addition to FSGS and co-deposition of other immunoglobulins had no significance.
OBJECTIVE: To find out the incidence and natural history of IgMN in India. METHODS: Renal biopsies of children ≤12 y age of last 6 y were retrospectively evaluated. Their clinical and biochemical presentation were correlated. Patients with systemic diseases/disorders were excluded from the study. RESULTS: Immunoglobulin M nephropathy (IgMN) constituted 11.9% (n = 28) of 236 renal biopsies. Mean age was 10 y, predominant in boys (n = 24), most of the patients presented with proteinuria and edema. The most common associated histopathological finding was mesangial proliferative glomerulonephritis (MePGN) in 60.7% (n = 17) followed by minimal change disease (MCD) in 28.6% (n = 8) and focal segmental glomerulosclerosis (FSGS) in 10.7% (n = 3). In 85.7%, IgM appeared as the sole immunoglobulin deposit mainly in mesangial regions, followed by accompanied C3 in 3.6% (n = 1) and C1q + C3 in 10.7% (n = 3) biopsies. CONCLUSIONS: IgMN was observed in 11.9% biopsies with commonest morphology of MePGN followed by MCD and FSGS; proteinuria was bad prognosticator in addition to FSGS and co-deposition of other immunoglobulins had no significance.
Authors: P M Zeis; E Kavazarakis; L Nakopoulou; M Moustaki; A Messaritaki; M P Zeis; P Nicolaidou Journal: Pediatr Int Date: 2001-06 Impact factor: 1.524
Authors: Kamal V Kanodia; Aruna V Vanikar; Lovelesh K Nigam; Rashmi D Patel; Kamlesh S Suthar; Dinesh N Gera; Hargovind L Trivedi Journal: Nephrourol Mon Date: 2015-06-28
Authors: Sung Woo Lee; Mi-Yeon Yu; Seon Ha Baek; Shin-Young Ahn; Sejoong Kim; Ki Young Na; Dong-Wan Chae; Ho Jun Chin Journal: PLoS One Date: 2016-01-22 Impact factor: 3.240