Aruna Vanikar1. 1. Department of Pathology, Laboratory Medicine and Transfusion Services and Department of Immunohematology, GR Doshi and KM Mehta Institute of Kidney Diseases & Research Centre, Gujarat, India.
Abstract
CONTEXT: IgM nephropathy (IgMN) is a relatively less recognized clinico-immunopathological entity in the domain of glomerulonephritis , often thought to be a bridge between minimal change disease and focal segmental glomerulosclerosis. EVIDENCE ACQUISITIONS: Directory of Open Access Journals (DOAJ), Google Scholar, Pubmed (NLM), LISTA (EBSCO) and Web of Science has been searched. RESULTS: IgM nephropathy can present as nephritic syndrome or less commonly with subnephrotic proteinuria or rarely hematuria. About 30% patients respond to steroids whereas others are steroid dependent / resistant. They should be given a trial of Rituximab or stem cell therapy. CONCLUSIONS: IgM nephropathy (IgMN) is an important and rather neglected pathology responsible for renal morbidity in children and adults in developing countries as compared to developed nations with incidence of 2-18.5% of native biopsies. Abnormal T-cell function with hyperfunctioning suppressor T-cells are believed to be responsible for this disease entity. Approximately one third of the patients are steroid responders where as the remaining two thirds are steroid resistant or dependent. Therapeutic trials including cell therapies targeting suppressor T-cells are required.
CONTEXT: IgM nephropathy (IgMN) is a relatively less recognized clinico-immunopathological entity in the domain of glomerulonephritis , often thought to be a bridge between minimal change disease and focal segmental glomerulosclerosis. EVIDENCE ACQUISITIONS: Directory of Open Access Journals (DOAJ), Google Scholar, Pubmed (NLM), LISTA (EBSCO) and Web of Science has been searched. RESULTS: IgM nephropathy can present as nephritic syndrome or less commonly with subnephrotic proteinuria or rarely hematuria. About 30% patients respond to steroids whereas others are steroid dependent / resistant. They should be given a trial of Rituximab or stem cell therapy. CONCLUSIONS: IgM nephropathy (IgMN) is an important and rather neglected pathology responsible for renal morbidity in children and adults in developing countries as compared to developed nations with incidence of 2-18.5% of native biopsies. Abnormal T-cell function with hyperfunctioning suppressor T-cells are believed to be responsible for this disease entity. Approximately one third of the patients are steroid responders where as the remaining two thirds are steroid resistant or dependent. Therapeutic trials including cell therapies targeting suppressor T-cells are required.
Authors: Iuliana Magdalena Starcea; Roxana Alexandra Bogos; Georgiana Scurtu; Mihaela Munteanu; Radu Russu; Vasile Valeriu Lupu; Ancuta Lupu; Laura Trandafir; Ingrith Crenguta Miron; Maria Adriana Mocanu Journal: Int J Gen Med Date: 2022-04-19
Authors: Kamal V Kanodia; Aruna V Vanikar; Lovelesh K Nigam; Rashmi D Patel; Kamlesh S Suthar; Dinesh N Gera; Hargovind L Trivedi Journal: Nephrourol Mon Date: 2015-06-28
Authors: Sung Woo Lee; Mi-Yeon Yu; Seon Ha Baek; Shin-Young Ahn; Sejoong Kim; Ki Young Na; Dong-Wan Chae; Ho Jun Chin Journal: PLoS One Date: 2016-01-22 Impact factor: 3.240