| Literature DB >> 22288716 |
Joel R Calvin1, Michael O Frederick, Dana L T Laird, Jacob R Remacle, Scott A May.
Abstract
The asymmetric hydrogenation of tetrasubstituted α,β-unsaturated ketones has been accomplished using an in situ formed rhodium-Josiphos catalyst. The reaction is enhanced by addition of catalytic zinc(II) triflate, which significantly improves turnover frequency while suppressing epimerization of the products.Entities:
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Year: 2012 PMID： 22288716 DOI： 10.1021/ol203264a
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005