BACKGROUND: Low serum levels of vitamin D, measured as serum 25-hydroxy-vitamin D (S-25-OHD), have been observed in several cancers. METHODS: Sixty-five adult patients with head and neck cancer, 50 men, median age 61 years (range, 33-77 years), were enrolled in this prospective cohort study. Concentrations of S-25-OHD and plasma calcium (Ca) and phosphate (Pi) were measured before cancer treatment. RESULTS: The mean S-25-OHD was 42.0 (SD 22) nmol/L. Hypovitaminosis D (37.5-50 nmol/L) was found in 20% of the patients and vitamin D deficiency (<37.5 nmol/L) in 45% of the patients. No seasonal variation was seen. Subnormal plasma Ca and Pi levels were found in 11% and 9% of the patients, respectively. CONCLUSION: Subnormal vitamin D levels were found in a significant proportion of the patients. Because vitamin D deficiency may pose these patients to increased risk of therapy-related morbidity, special attention should be paid to correction of this nutritional deficiency.
BACKGROUND: Low serum levels of vitamin D, measured as serum 25-hydroxy-vitamin D (S-25-OHD), have been observed in several cancers. METHODS: Sixty-five adult patients with head and neck cancer, 50 men, median age 61 years (range, 33-77 years), were enrolled in this prospective cohort study. Concentrations of S-25-OHD and plasma calcium (Ca) and phosphate (Pi) were measured before cancer treatment. RESULTS: The mean S-25-OHD was 42.0 (SD 22) nmol/L. Hypovitaminosis D (37.5-50 nmol/L) was found in 20% of the patients and vitamin D deficiency (<37.5 nmol/L) in 45% of the patients. No seasonal variation was seen. Subnormal plasma Ca and Pi levels were found in 11% and 9% of the patients, respectively. CONCLUSION: Subnormal vitamin D levels were found in a significant proportion of the patients. Because vitamin D deficiency may pose these patients to increased risk of therapy-related morbidity, special attention should be paid to correction of this nutritional deficiency.
Authors: Adrianna Mostowska; Stefan Sajdak; Piotr Pawlik; Margarita Lianeri; Paweł P Jagodzinski Journal: Oncol Lett Date: 2015-12-15 Impact factor: 2.967
Authors: Eva B Yokosawa; Anna E Arthur; Katie M Rentschler; Gregory T Wolf; Laura S Rozek; Alison M Mondul Journal: Laryngoscope Date: 2018-05-14 Impact factor: 3.325
Authors: Florian Bochen; Benedikt Balensiefer; Sandrina Körner; Jörg Thomas Bittenbring; Frank Neumann; Armand Koch; Klaus Bumm; Anke Marx; Silke Wemmert; Georgios Papaspyrou; David Zuschlag; Jan Philipp Kühn; Basel Al Kadah; Bernhard Schick; Maximilian Linxweiler Journal: Oncoimmunology Date: 2018-07-23 Impact factor: 8.110