H Zhang1, H Lu1, C Shrestha1, Y Feng2, Y Li3, J Peng1, Y Li3, Z Xie1. 1. Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, PRC; 2. Department of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, PRC; 3. Stomatological Hospital of Xiangtan, Xiangtan, PRC.
Abstract
INTRODUCTION: Vitamin D and calcium are known to regulate differentiation and proliferation of keratinocytes; they might potentially have a role in suppressing carcinogenesis in squamous epithelium. Serum parathyroid hormone (pth) is a sensitive indicator of calcium and vitamin D deficiency, and 25-hydroxyvitamin D [25(OH)D] is an established marker of vitamin D status. METHODS: To determine whether levels of 25(OH)D, calcium, or pth in serum are associated with oral squamous cell carcinoma (oscc), we examined those parameters in serum collected from 70 patients with oscc and from an equal number of matched control subjects. RESULTS: The results showed that intact pth was significantly higher in serum from oscc patients than in serum from control subjects. However, we observed no significant differences in 25(OH)D or calcium in serum from oscc patients and from control subjects. CONCLUSIONS: We conclude that higher serum pth, but not lower serum vitamin D or calcium, is associated with oscc.
INTRODUCTION:Vitamin D and calcium are known to regulate differentiation and proliferation of keratinocytes; they might potentially have a role in suppressing carcinogenesis in squamous epithelium. Serum parathyroid hormone (pth) is a sensitive indicator of calcium and vitamin D deficiency, and 25-hydroxyvitamin D [25(OH)D] is an established marker of vitamin D status. METHODS: To determine whether levels of 25(OH)D, calcium, or pth in serum are associated with oral squamous cell carcinoma (oscc), we examined those parameters in serum collected from 70 patients with oscc and from an equal number of matched control subjects. RESULTS: The results showed that intact pth was significantly higher in serum from oscc patients than in serum from control subjects. However, we observed no significant differences in 25(OH)D or calcium in serum from oscc patients and from control subjects. CONCLUSIONS: We conclude that higher serum pth, but not lower serum vitamin D or calcium, is associated with oscc.
Authors: Hannah Arem; Stephanie J Weinstein; Ronald L Horst; Jarmo Virtamo; Kai Yu; Demetrius Albanes; Christian C Abnet Journal: Cancer Epidemiol Biomarkers Prev Date: 2011-04-28 Impact factor: 4.254
Authors: Christian C Abnet; Yu Chen; Wong-Ho Chow; Yu-Tang Gao; Kathy J Helzlsouer; Loïc Le Marchand; Marjorie L McCullough; James M Shikany; Jarmo Virtamo; Stephanie J Weinstein; Yong-Bing Xiang; Kai Yu; Wei Zheng; Demetrius Albanes; Alan A Arslan; David S Campbell; Peter T Campbell; Richard B Hayes; Ronald L Horst; Laurence N Kolonel; Abraham M Y Nomura; Mark P Purdue; Kirk Snyder; Xiao-Ou Shu Journal: Am J Epidemiol Date: 2010-06-18 Impact factor: 4.897