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Literature DB >> 22286818

Emerging roles of SIRT6 on telomere maintenance, DNA repair, metabolism and mammalian aging.

Gaoxiang Jia¹, Ling Su, Sunil Singhal, Xiangguo Liu.

Abstract

With the characterization of Sir2 gene in yeast aging, its mammalian homologs Sirtuins 1–7 have been attracting attention from scientists with various research backgrounds. Among Sirtuins, SIRT1 is the most extensively studied. Recent progress on mammalian Sirtuins has shown that SIRT6 as a histone deacetylase may also play a critical role in regulating mammalian aging. This review summarizes recent advances on SIRT6 as a key modulator of telomere structure, DNA repair, metabolism, and NF-kappa B pathway in aging. In addition, we discuss the challenges that remain to be studied in SIRT6 biology.

Entities: Gene Species

Mesh：

Substances：

Year: 2012 PMID： 22286818 DOI： 10.1007/s11010-012-1236-8

Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396

69 in total

1. The Stability of Broken Ends of Chromosomes in Zea Mays.

Authors: B McClintock
Journal: Genetics Date: 1941-03 Impact factor: 4.562

2. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.

Authors: Raul Mostoslavsky; Katrin F Chua; David B Lombard; Wendy W Pang; Miriam R Fischer; Lionel Gellon; Pingfang Liu; Gustavo Mostoslavsky; Sonia Franco; Michael M Murphy; Kevin D Mills; Parin Patel; Joyce T Hsu; Andrew L Hong; Ethan Ford; Hwei-Ling Cheng; Caitlin Kennedy; Nomeli Nunez; Roderick Bronson; David Frendewey; Wojtek Auerbach; David Valenzuela; Margaret Karow; Michael O Hottiger; Stephen Hursting; J Carl Barrett; Leonard Guarente; Richard Mulligan; Bruce Demple; George D Yancopoulos; Frederick W Alt
Journal: Cell Date: 2006-01-27 Impact factor: 41.582

3. SIRT6 promotes DNA repair under stress by activating PARP1.

Authors: Zhiyong Mao; Christopher Hine; Xiao Tian; Michael Van Meter; Matthew Au; Amita Vaidya; Andrei Seluanov; Vera Gorbunova
Journal: Science Date: 2011-06-17 Impact factor: 47.728

4. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.

Authors: M Kaeberlein; M McVey; L Guarente
Journal: Genes Dev Date: 1999-10-01 Impact factor: 11.361

Review 5. Autophagy and aging.

Authors: David C Rubinsztein; Guillermo Mariño; Guido Kroemer
Journal: Cell Date: 2011-09-02 Impact factor: 41.582

6. SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair.

Authors: Ronald A McCord; Eriko Michishita; Tao Hong; Elisabeth Berber; Lisa D Boxer; Rika Kusumoto; Shenheng Guan; Xiaobing Shi; Or Gozani; Alma L Burlingame; Vilhelm A Bohr; Katrin F Chua
Journal: Aging (Albany NY) Date: 2009-01-15 Impact factor: 5.682

7. Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6.

Authors: Eriko Michishita; Ronald A McCord; Lisa D Boxer; Matthew F Barber; Tao Hong; Or Gozani; Katrin F Chua
Journal: Cell Cycle Date: 2009-08-26 Impact factor: 4.534

Review 8. Autophagy and NF-kappaB: fight for fate.

Authors: Gutian Xiao
Journal: Cytokine Growth Factor Rev Date: 2007-05-07 Impact factor: 7.638

9. DNA sequences of telomeres maintained in yeast.

Authors: J Shampay; J W Szostak; E H Blackburn
Journal: Nature Date: 1984 Jul 12-18 Impact factor: 49.962

Review 10. Sirtuins in mammals: insights into their biological function.

Authors: Shaday Michan; David Sinclair
Journal: Biochem J Date: 2007-05-15 Impact factor: 3.857

27 in total

Review 1. Sirtuins, aging, and cardiovascular risks.

Authors: Gaia Favero; Lorenzo Franceschetti; Luigi Fabrizio Rodella; Rita Rezzani
Journal: Age (Dordr) Date: 2015-06-23

Review 2. SIRT6, a Mammalian Deacylase with Multitasking Abilities.

Authors: Andrew R Chang; Christina M Ferrer; Raul Mostoslavsky
Journal: Physiol Rev Date: 2019-08-22 Impact factor: 37.312

3. The guardian: metabolic and tumour-suppressive effects of SIRT6.

Authors: Batya Lerrer; Haim Y Cohen
Journal: EMBO J Date: 2012-12-11 Impact factor: 11.598

Review 4. Basic Biology of Oxidative Stress and the Cardiovascular System: Part 1 of a 3-Part Series.

Authors: Michael N Sack; Frej Y Fyhrquist; Outi J Saijonmaa; Valentin Fuster; Jason C Kovacic
Journal: J Am Coll Cardiol Date: 2017-07-11 Impact factor: 24.094

Review 5. Defining a genotoxic profile with mouse embryonic stem cells.

Authors: Tae Moon Kim; Vivienne I Rebel; Paul Hasty
Journal: Exp Biol Med (Maywood) Date: 2013-03

6. A miR-34a-SIRT6 axis in the squamous cell differentiation network.

Authors: Karine Lefort; Yang Brooks; Paola Ostano; Muriel Cario-André; Valérie Calpini; Juan Guinea-Viniegra; Andrea Albinger-Hegyi; Wolfram Hoetzenecker; Ingrid Kolfschoten; Erwin F Wagner; Sabine Werner; Gian Paolo Dotto
Journal: EMBO J Date: 2013-07-16 Impact factor: 11.598

Review 7. The Role of Sirtuins in Antioxidant and Redox Signaling.

Authors: Chandra K Singh; Gagan Chhabra; Mary Ann Ndiaye; Liz Mariely Garcia-Peterson; Nicholas J Mack; Nihal Ahmad
Journal: Antioxid Redox Signal Date: 2017-10-20 Impact factor: 8.401

8. A proteomic perspective of Sirtuin 6 (SIRT6) phosphorylation and interactions and their dependence on its catalytic activity.

Authors: Yana V Miteva; Ileana M Cristea
Journal: Mol Cell Proteomics Date: 2013-10-25 Impact factor: 5.911

9. DNA Methylation of Telomere-Related Genes and Cancer Risk.

Authors: Brian T Joyce; Yinan Zheng; Drew Nannini; Zhou Zhang; Lei Liu; Tao Gao; Masha Kocherginsky; Robert Murphy; Hushan Yang; Chad J Achenbach; Lewis R Roberts; Mirjam Hoxha; Jincheng Shen; Pantel Vokonas; Joel Schwartz; Andrea Baccarelli; Lifang Hou
Journal: Cancer Prev Res (Phila) Date: 2018-06-12

Review 10. Fueling the flame: bioenergy couples metabolism and inflammation.

Authors: Tie Fu Liu; Candice M Brown; Mohamed El Gazzar; Linda McPhail; Patrick Millet; Anuradha Rao; Vidula T Vachharajani; Barbara K Yoza; Charles E McCall
Journal: J Leukoc Biol Date: 2012-05-09 Impact factor: 4.962