Literature DB >> 26099749

Sirtuins, aging, and cardiovascular risks.

Gaia Favero1, Lorenzo Franceschetti, Luigi Fabrizio Rodella, Rita Rezzani.   

Abstract

The sirtuins comprise a highly conserved family proteins present in virtually all species from bacteria to mammals. Sirtuins are members of the highly conserved class III histone deacetylases, and seven sirtuin genes (sirtuins 1-7) have been identified and characterized in mammals. Sirtuin activity is linked to metabolic control, apoptosis, cell survival, development, inflammation, and healthy aging. In this review, we summarize and discuss the potential mutual relations between each sirtuin and cardiovascular health and the impact of sirtuins on oxidative stress and so age-related cardiovascular disorders, underlining the possibility that sirtuins will be novel targets to contrast cardiovascular risks induced by aging.

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Year:  2015        PMID： 26099749      PMCID： PMC4476976          DOI： 10.1007/s11357-015-9804-y

Source DB:  PubMed          Journal:  Age (Dordr)        ISSN： 0161-9152


  191 in total

1.  Transcriptional and phenotypic changes in aorta and aortic valve with aging and MnSOD deficiency in mice.

Authors:  Carolyn M Roos; Michael Hagler; Bin Zhang; Elise A Oehler; Arman Arghami; Jordan D Miller
Journal:  Am J Physiol Heart Circ Physiol       Date:  2013-08-30       Impact factor: 4.733

2.  Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.

Authors:  Raul Mostoslavsky; Katrin F Chua; David B Lombard; Wendy W Pang; Miriam R Fischer; Lionel Gellon; Pingfang Liu; Gustavo Mostoslavsky; Sonia Franco; Michael M Murphy; Kevin D Mills; Parin Patel; Joyce T Hsu; Andrew L Hong; Ethan Ford; Hwei-Ling Cheng; Caitlin Kennedy; Nomeli Nunez; Roderick Bronson; David Frendewey; Wojtek Auerbach; David Valenzuela; Margaret Karow; Michael O Hottiger; Stephen Hursting; J Carl Barrett; Leonard Guarente; Richard Mulligan; Bruce Demple; George D Yancopoulos; Frederick W Alt
Journal:  Cell       Date:  2006-01-27       Impact factor: 41.582

3.  Modulation of SIRT1 expression in different neurodegenerative models and human pathologies.

Authors:  M Pallàs; J G Pizarro; J Gutierrez-Cuesta; N Crespo-Biel; D Alvira; M Tajes; M Yeste-Velasco; J Folch; A M Canudas; F X Sureda; I Ferrer; A Camins
Journal:  Neuroscience       Date:  2008-05-03       Impact factor: 3.590

4.  Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1.

Authors:  Masaya Tanno; Jun Sakamoto; Tetsuji Miura; Kazuaki Shimamoto; Yoshiyuki Horio
Journal:  J Biol Chem       Date:  2006-12-30       Impact factor: 5.157

5.  Characterization of a bidirectional promoter shared between two human genes related to aging: SIRT3 and PSMD13.

Authors:  D Bellizzi; S Dato; P Cavalcante; G Covello; F Di Cianni; G Passarino; G Rose; G De Benedictis
Journal:  Genomics       Date:  2006-10-23       Impact factor: 5.736

6.  The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.

Authors:  M Kaeberlein; M McVey; L Guarente
Journal:  Genes Dev       Date:  1999-10-01       Impact factor: 11.361

7.  Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.

Authors:  Konrad T Howitz; Kevin J Bitterman; Haim Y Cohen; Dudley W Lamming; Siva Lavu; Jason G Wood; Robert E Zipkin; Phuong Chung; Anne Kisielewski; Li-Li Zhang; Brandy Scherer; David A Sinclair
Journal:  Nature       Date:  2003-08-24       Impact factor: 49.962

Review 8.  Sorting out functions of sirtuins in cancer.

Authors:  M Roth; W Y Chen
Journal:  Oncogene       Date:  2013-04-22       Impact factor: 9.867

9.  Endothelial sirtuin 1 deficiency perpetrates nephrosclerosis through downregulation of matrix metalloproteinase-14: relevance to fibrosis of vascular senescence.

Authors:  Radovan Vasko; Sandhya Xavier; Jun Chen; Chi Hua Sarah Lin; Brian Ratliff; May Rabadi; Julien Maizel; Rina Tanokuchi; Frank Zhang; Jian Cao; Michael S Goligorsky
Journal:  J Am Soc Nephrol       Date:  2013-10-17       Impact factor: 10.121

10.  The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression.

Authors:  Melroy X Miranda; Lambertus J van Tits; Christine Lohmann; Tasneem Arsiwala; Stephan Winnik; Anne Tailleux; Sokrates Stein; Ana P Gomes; Vipin Suri; James L Ellis; Thomas A Lutz; Michael O Hottiger; David A Sinclair; Johan Auwerx; Kristina Schoonjans; Bart Staels; Thomas F Lüscher; Christian M Matter
Journal:  Eur Heart J       Date:  2014-03-06       Impact factor: 29.983
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  15 in total

1.  Effect of long-term treatment with melatonin on vascular markers of oxidative stress/inflammation and on the anticontractile activity of perivascular fat in aging mice.

Authors:  Claudia Agabiti-Rosei; Gaia Favero; Carolina De Ciuceis; Claudia Rossini; Enzo Porteri; Luigi Fabrizio Rodella; Lorenzo Franceschetti; Anna Maria Sarkar; Enrico Agabiti-Rosei; Damiano Rizzoni; Rita Rezzani
Journal:  Hypertens Res       Date:  2016-08-18       Impact factor: 3.872

Review 2.  Erythropoietin and mTOR: A "One-Two Punch" for Aging-Related Disorders Accompanied by Enhanced Life Expectancy.

Authors:  Kenneth Maiese
Journal:  Curr Neurovasc Res       Date:  2016       Impact factor: 1.990

Review 3.  Harnessing the Power of SIRT1 and Non-coding RNAs in Vascular Disease.

Authors:  Kenneth Maiese
Journal:  Curr Neurovasc Res       Date:  2017       Impact factor: 1.990

Review 4.  Pharmacological basis and new insights of resveratrol action in the cardiovascular system.

Authors:  Chak Kwong Cheng; Jiang-Yun Luo; Chi Wai Lau; Zhen-Yu Chen; Xiao Yu Tian; Yu Huang
Journal:  Br J Pharmacol       Date:  2019-12-08       Impact factor: 8.739

5.  Hsp90 inhibition suppresses NF-κB transcriptional activation via Sirt-2 in human lung microvascular endothelial cells.

Authors:  Gagan S Thangjam; Charalampos Birmpas; Nektarios Barabutis; Betsy W Gregory; Mary Ann Clemens; Joseph R Newton; David Fulton; John D Catravas
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2016-04-01       Impact factor: 5.464

Review 6.  Cognitive impairment with diabetes mellitus and metabolic disease: innovative insights with the mechanistic target of rapamycin and circadian clock gene pathways.

Authors:  Kenneth Maiese
Journal:  Expert Rev Clin Pharmacol       Date:  2020-01-03       Impact factor: 5.045

7.  Regeneration in the nervous system with erythropoietin.

Authors:  Kenneth Maiese
Journal:  Front Biosci (Landmark Ed)       Date:  2016-01

8.  The investigation of the role of sirtuin-1 on embryo implantation in oxidative stress-induced mice.

Authors:  Kubra Aksu; Ezgi Golal; Mutay Aydın Aslan; Ismail Ustunel; Nuray Acar
Journal:  J Assist Reprod Genet       Date:  2021-05-15       Impact factor: 3.357

Review 9.  Novel nervous and multi-system regenerative therapeutic strategies for diabetes mellitus with mTOR.

Authors:  Kenneth Maiese
Journal:  Neural Regen Res       Date:  2016-03       Impact factor: 5.135

10.  Hepatic Macrosteatosis Is Partially Converted to Microsteatosis by Melatonin Supplementation in ob/ob Mice Non-Alcoholic Fatty Liver Disease.

Authors:  Alessandra Stacchiotti; Gaia Favero; Antonio Lavazza; Igor Golic; Marija Aleksic; Aleksandra Korac; Luigi Fabrizio Rodella; Rita Rezzani
Journal:  PLoS One       Date:  2016-01-29       Impact factor: 3.240
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