OBJECTIVES: To assess the effect of prenatal diagnosis of congenital heart disease on neurocognitive outcomes in children with d-transposition of the great arteries (TGA) after surgical correction. STUDY DESIGN: A prospective study of children born with a TGA between 2003 and 2005 and aged 4 to 6 years was conducted. General intelligence, language, executive functions, and social cognition scores and preoperative, intraoperative, and postoperative factors were evaluated according to time of TGA diagnosis. Neurocognitive data were also compared with a control group. RESULTS: Forty-five eligible patients (67% male) were examined; 29 had a prenatal diagnosis of TGA and 16 did not. All children were comparable in age, sex, and demographic variables. Diagnostic groups did not differ in preoperative, intraoperative, and postoperative variables. Preoperative acidosis was more frequent in the postnatal group (18% versus 3%). All patients had normal IQ scores, language, and verbal working memory. However, neurocognitive deficits were more prevalent and more severe in children with a postnatal-TGA. Prenatal diagnosis was associated with better outcomes in executive functions. CONCLUSIONS: Prenatal diagnosis of TGA is associated with better neurocognitive outcomes. Time of diagnosis may influence the development of early complex cognitive skills such as executive functions.
OBJECTIVES: To assess the effect of prenatal diagnosis of congenital heart disease on neurocognitive outcomes in children with d-transposition of the great arteries (TGA) after surgical correction. STUDY DESIGN: A prospective study of children born with a TGA between 2003 and 2005 and aged 4 to 6 years was conducted. General intelligence, language, executive functions, and social cognition scores and preoperative, intraoperative, and postoperative factors were evaluated according to time of TGA diagnosis. Neurocognitive data were also compared with a control group. RESULTS: Forty-five eligible patients (67% male) were examined; 29 had a prenatal diagnosis of TGA and 16 did not. All children were comparable in age, sex, and demographic variables. Diagnostic groups did not differ in preoperative, intraoperative, and postoperative variables. Preoperative acidosis was more frequent in the postnatal group (18% versus 3%). All patients had normal IQ scores, language, and verbal working memory. However, neurocognitive deficits were more prevalent and more severe in children with a postnatal-TGA. Prenatal diagnosis was associated with better outcomes in executive functions. CONCLUSIONS: Prenatal diagnosis of TGA is associated with better neurocognitive outcomes. Time of diagnosis may influence the development of early complex cognitive skills such as executive functions.
Authors: Shabnam Peyvandi; Veronica De Santiago; Elavazhagan Chakkarapani; Vann Chau; Andrew Campbell; Kenneth J Poskitt; Duan Xu; A James Barkovich; Steven Miller; Patrick McQuillen Journal: JAMA Pediatr Date: 2016-04-04 Impact factor: 16.193
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Authors: Shabnam Peyvandi; Vann Chau; Ting Guo; Duan Xu; Hannah C Glass; Anne Synnes; Kenneth Poskitt; A James Barkovich; Steven P Miller; Patrick S McQuillen Journal: J Am Coll Cardiol Date: 2018-05-08 Impact factor: 24.094
Authors: M C Escobar-Diaz; L R Freud; A Bueno; D W Brown; K G Friedman; D Schidlow; S Emani; P J Del Nido; W Tworetzky Journal: Ultrasound Obstet Gynecol Date: 2015-04-30 Impact factor: 7.299
Authors: Adam R Cassidy; Matthew T White; David R DeMaso; Jane W Newburger; David C Bellinger Journal: J Int Neuropsychol Soc Date: 2014-12-09 Impact factor: 2.892
Authors: Juan Villafañe; M Regina Lantin-Hermoso; Ami B Bhatt; James S Tweddell; Tal Geva; Meena Nathan; Martin J Elliott; Victoria L Vetter; Stephen M Paridon; Lazaros Kochilas; Kathy J Jenkins; Robert H Beekman; Gil Wernovsky; Jeffrey A Towbin Journal: J Am Coll Cardiol Date: 2014-08-05 Impact factor: 24.094