Literature DB >> 22279045

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia.

Stefan P Glaser1, Erinna F Lee, Evelyn Trounson, Philippe Bouillet, Andrew Wei, W Douglas Fairlie, David J Izon, Johannes Zuber, Amy R Rappaport, Marco J Herold, Warren S Alexander, Scott W Lowe, Lorraine Robb, Andreas Strasser.   

Abstract

Acute myeloid leukemia (AML) frequently relapses after initial treatment. Drug resistance in AML has been attributed to high levels of the anti-apoptotic Bcl-2 family members Bcl-x(L) and Mcl-1. Here we report that removal of Mcl-1, but not loss or pharmacological blockade of Bcl-x(L), Bcl-2, or Bcl-w, caused the death of transformed AML and could cure disease in AML-afflicted mice. Enforced expression of selective inhibitors of prosurvival Bcl-2 family members revealed that Mcl-1 is critical for survival of human AML cells. Thus, targeting of Mcl-1 or regulators of its expression may be a useful strategy for the treatment of AML.

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Year:  2012        PMID： 22279045      PMCID： PMC3273836          DOI： 10.1101/gad.182980.111

Source DB:  PubMed          Journal:  Genes Dev        ISSN： 0890-9369            Impact factor:   11.361


  30 in total

1.  Mcl-1 is essential for germinal center formation and B cell memory.

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Journal:  Science       Date:  2010-10-07       Impact factor: 47.728

2.  A practical summary of site-specific recombination, conditional mutagenesis, and tamoxifen induction of CreERT2.

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3.  Polycystic kidney disease prevented by transgenic RNA interference.

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Journal:  Cell Death Differ       Date:  2005-07       Impact factor: 15.828

4.  Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice.

Authors:  C Lavau; R T Luo; C Du; M J Thirman
Journal:  Proc Natl Acad Sci U S A       Date:  2000-09-26       Impact factor: 11.205

5.  Enforced expression of the homeobox gene Mixl1 impairs hematopoietic differentiation and results in acute myeloid leukemia.

Authors:  Stefan Glaser; Donald Metcalf; Li Wu; Adam H Hart; Ladina DiRago; Sandra Mifsud; Angela D'Amico; Samantha Dagger; Chiara Campo; Angela C Chan; David J Izon; Lorraine Robb
Journal:  Proc Natl Acad Sci U S A       Date:  2006-10-23       Impact factor: 11.205

6.  Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse.

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Authors:  B Jiao; C-F Wu; Y Liang; H-M Chen; S-M Xiong; B Chen; J-Y Shi; Y-Y Wang; J-H Wang; Y Chen; J-M Li; L-J Gu; J-Y Tang; Z-X Shen; B-W Gu; W-L Zhao; Z Chen; S-J Chen
Journal:  Leukemia       Date:  2009-05-21       Impact factor: 11.528

9.  The preleukemic state of mice reconstituted with Mixl1-transduced marrow cells.

Authors:  Donald Metcalf; Stefan Glaser; Sandra Mifsud; Ladina Di Rago; Lorraine Robb
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10.  Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells.

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  179 in total

1.  FBXO4 inhibits lung cancer cell survival by targeting Mcl-1 for degradation.

Authors:  C Feng; F Yang; J Wang
Journal:  Cancer Gene Ther       Date:  2017-08-04       Impact factor: 5.987

2.  Selectively targeting Mcl-1 for the treatment of acute myelogenous leukemia and solid tumors.

Authors:  Gregory J Gores; Scott H Kaufmann
Journal:  Genes Dev       Date:  2012-02-15       Impact factor: 11.361

3.  α/β-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells.

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Review 4.  Pathways and mechanisms of venetoclax resistance.

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Journal:  Leuk Lymphoma       Date:  2017-01-31

Review 5.  Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.

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Journal:  Nat Rev Mol Cell Biol       Date:  2014-01       Impact factor: 94.444

6.  PI3K inhibitor GDC-0941 enhances apoptotic effects of BH-3 mimetic ABT-737 in AML cells in the hypoxic bone marrow microenvironment.

Authors:  Linhua Jin; Yoko Tabe; Kensuke Kojima; Masato Shikami; Julina Benito; Vivian Ruvolo; Rui-Yu Wang; Teresa McQueen; Stefan O Ciurea; Takashi Miida; Michael Andreeff; Marina Konopleva
Journal:  J Mol Med (Berl)       Date:  2013-08-18       Impact factor: 4.599

7.  Seeking a MCL-1 inhibitor.

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Journal:  Cell Death Differ       Date:  2013-11       Impact factor: 15.828

8.  RepSox slows decay of CD34+ acute myeloid leukemia cells and decreases T cell immunoglobulin mucin-3 expression.

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Journal:  Proc Natl Acad Sci U S A       Date:  2013-03-26       Impact factor: 11.205

10.  Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism.

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Journal:  Cancer Res       Date:  2012-12-12       Impact factor: 12.701
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