| Literature DB >> 22277681 |
Jorge J Castillo1, Brady E Beltran, Moo-Kon Song, Ivana Ilic, Sirpa Leppa, Heidi Nurmi, Ritsuko Seki, Silvia Uccella, Jun-Min Li, Diana O Treaba, Dariusz Stachurski, James N Butera.
Abstract
Our objective was to evaluate the non-germinal center (GC) profile as a marker for response and survival in DLBCL and to compare the characteristics of patients with GC and non-GC DLBCL treated with rituximab-containing regimens. In this patient-level meta-analysis, retrospective data from 712 newly diagnosed DLBCL patients treated with chemoimmunotherapy from 7 centers were analyzed. GC and non-GC profiles were defined according to the Hans algorithm. Although the non-GC profile showed a trend towards worse overall survival (HR 1.24, 95% CI 0.92-1.66; p=0.15) and progression-free survival (HR 1.29, 95% CI 0.96-1.73; p=0.09), it did not retain its value in the multivariate survival analysis. Additionally, the non-GC profile was independently associated with worse complete response rates (OR 0.55, 95% CI 0.37-0.83; p<0.01) in the multivariate logistic regression analysis. Interestingly, Asian patients had higher proportion of GC DLBCL (p=0.01).Entities:
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Year: 2012 PMID： 22277681 DOI： 10.1016/j.leukres.2011.12.012
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156