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Literature DB >> 22276851

Caspase-1 and -3 inhibiting drimane sesquiterpenoids from the extremophilic fungus Penicillium solitum.

Donald B Stierle¹, Andrea A Stierle, Teri Girtsman, Kyle McIntyre, Jesse Nichols.

Abstract

Two new drimane sesquiterpene lactones and one new tricarboxylic acid derivative were isolated from the Berkeley Pit extremophilic fungus Penicillium solitum. The structures of these compounds were deduced by spectroscopic analysis. Berkedrimanes A and B inhibited the signal transduction enzymes caspase-1 and caspase-3 and mitigated the production of interleukin 1-β in the induced THP-1 (pro-monocytic leukemia cell line) assay.

Entities: CellLine Chemical Disease Gene Species

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Year: 2012 PMID： 22276851 PMCID： PMC3330828 DOI： 10.1021/np200528n

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

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