Literature DB >> 22271864

In vitro potency and in vivo efficacy of a novel bis-indole antimicrobial compound in reducing catheter colonization.

Mohammad D Mansouri1, Timothy J Opperman, John D Williams, Charles Stager, Rabih O Darouiche.   

Abstract

Vascular catheters coated with a novel antimicrobial agent (MBX1631) were studied for their ability to protect against bacterial colonization in vitro and in a rabbit model. MBX1631-coated catheters were significantly less likely to become colonized than control catheters both in vitro and in vivo (P < 0.001). Furthermore, device-associated infection was significantly lower in MBX1631-coated catheters than in uncoated ones (P < 0.005).

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Year:  2012        PMID： 22271864      PMCID： PMC3318368          DOI： 10.1128/AAC.05521-11

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  Meta-analysis: methods for diagnosing intravascular device-related bloodstream infection.

Authors:  Nasia Safdar; Jason P Fine; Dennis G Maki
Journal:  Ann Intern Med       Date:  2005-03-15       Impact factor: 25.391

Review 2.  Intravascular catheter-related infections: advances in diagnosis, prevention, and management.

Authors:  Issam Raad; Hend Hanna; Dennis Maki
Journal:  Lancet Infect Dis       Date:  2007-10       Impact factor: 25.071

3.  Device-associated nosocomial infections in 55 intensive care units of 8 developing countries.

Authors:  Victor D Rosenthal; Dennis G Maki; Reinaldo Salomao; Carlos Alvarez Moreno; Yatin Mehta; Francisco Higuera; Luis E Cuellar; Ozay Akan Arikan; Rédouane Abouqal; Hakan Leblebicioglu
Journal:  Ann Intern Med       Date:  2006-10-17       Impact factor: 25.391

4.  Use of antibiotic - impregnated DuraGen® to reduce the risk of infection in dura repair: an in vitro study.

Authors:  M Kaplan; B Akgun; K Demirdag; N Akpolat; S K Kozan; O Cagasar; H Yakar
Journal:  Cent Eur Neurosurg       Date:  2011-02-22

5.  The Role of Intravascular Devices in Sepsis.

Authors:  Christopher J. Crnich; Dennis G. Maki
Journal:  Curr Infect Dis Rep       Date:  2001-12       Impact factor: 3.725

6.  Evaluation of outcome of intravenous catheter-related infections in critically ill patients.

Authors:  J Rello; A Ochagavia; E Sabanes; M Roque; D Mariscal; E Reynaga; J Valles
Journal:  Am J Respir Crit Care Med       Date:  2000-09       Impact factor: 21.405

7.  Guidelines for the prevention of intravascular catheter-related infections. Centers for Disease Control and Prevention.

Authors:  Naomi P O'Grady; Mary Alexander; E Patchen Dellinger; Julie L Gerberding; Stephen O Heard; Dennis G Maki; Henry Masur; Rita D McCormick; Leonard A Mermel; Michele L Pearson; Issam I Raad; Adrienne Randolph; Robert A Weinstein
Journal:  MMWR Recomm Rep       Date:  2002-08-09

8.  Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.

Authors:  Rekha G Panchal; Ricky L Ulrich; Douglas Lane; Michelle M Butler; Chad Houseweart; Timothy Opperman; John D Williams; Norton P Peet; Donald T Moir; Tam Nguyen; Rick Gussio; Terry Bowlin; Sina Bavari
Journal:  Antimicrob Agents Chemother       Date:  2009-07-27       Impact factor: 5.191

9.  Comparative assessment of antimicrobial activities of antibiotic-treated penile prostheses.

Authors:  Mohammad D Mansouri; Timothy B Boone; Rabih O Darouiche
Journal:  Eur Urol       Date:  2008-12-30       Impact factor: 20.096

10.  The broad-spectrum activity and efficacy of catheters coated with minocycline and rifampin.

Authors:  I Raad; R Darouiche; R Hachem; M Mansouri; G P Bodey
Journal:  J Infect Dis       Date:  1996-02       Impact factor: 5.226
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Journal:  Eur J Med Chem       Date:  2013-02-28       Impact factor: 6.514

2.  Synthesis, anti-leishmanial and molecular docking study of bis-indole derivatives.

Authors:  Muhammad Taha; Imad Uddin; Mohammed Gollapalli; Noor Barak Almandil; Fazal Rahim; Rai Khalid Farooq; Muhammad Nawaz; Mohamed Ibrahim; Mohammed A Alqahtani; Yasser A Bamarouf; Manikandan Selvaraj
Journal:  BMC Chem       Date:  2019-08-06
  2 in total

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