Jean-Louis Richard1, Jean-Philippe Lavigne, Albert Sotto. 1. Department of Diabetology and Nutritional Diseases, Medical Centre, University Hospital of Nîmes, 30240, Le Grau du Roi, France. jean.louis.richard@chu-nimes.fr
Abstract
BACKGROUND: Infection of foot ulcers is a common, often severe and costly complication in diabetes. Many factors linked to the host, mainly immune defects, neuropathy and arteriopathy, as well as bacteria-related factors, interact in a complex way and account for the susceptibility of diabetic individuals to foot infections, the severity of such infections and difficulty to treat them. METHODS: This article reviews these factors, in the light of data from the literature and from our own results. RESULTS: DFIs are not as simple as previously suggested, and new concepts must be considered, especially the virulence potential of isolates and bacterial communications through biofilms. CONCLUSION: The development of new tools from molecular biology is a critical step to better understand and manage these infections.
BACKGROUND: Infection of foot ulcers is a common, often severe and costly complication in diabetes. Many factors linked to the host, mainly immune defects, neuropathy and arteriopathy, as well as bacteria-related factors, interact in a complex way and account for the susceptibility of diabetic individuals to foot infections, the severity of such infections and difficulty to treat them. METHODS: This article reviews these factors, in the light of data from the literature and from our own results. RESULTS: DFIs are not as simple as previously suggested, and new concepts must be considered, especially the virulence potential of isolates and bacterial communications through biofilms. CONCLUSION: The development of new tools from molecular biology is a critical step to better understand and manage these infections.
Authors: Jean-Philippe Lavigne; Albert Sotto; Catherine Dunyach-Remy; Benjamin A Lipsky Journal: Adv Wound Care (New Rochelle) Date: 2015-01-01 Impact factor: 4.730
Authors: E Andrea Nelson; Michael Ross Backhouse; Moninder S Bhogal; Alexandra Wright-Hughes; Benjamin A Lipsky; Jane Nixon; Sarah Brown; Janine Gray Journal: BMJ Open Date: 2013-01-04 Impact factor: 2.692
Authors: Andrea Nelson; Alexandra Wright-Hughes; Michael Ross Backhouse; Benjamin A Lipsky; Jane Nixon; Moninder S Bhogal; Catherine Reynolds; Sarah Brown Journal: BMJ Open Date: 2018-01-31 Impact factor: 2.692