Literature DB >> 22270685

Cathechol-O-methyltransferase Val(158)Met polymorphism is associated with disruptive behavior disorders among children and adolescents with ADHD.

Angélica Salatino-Oliveira1, Julia P Genro, Ana P Guimarães, Rodrigo Chazan, Cristian Zeni, Marcelo Schmitz, Guilherme Polanczyk, Tatiana Roman, Luis A Rohde, Mara H Hutz.   

Abstract

COMT Val(158)Met polymorphism has been associated with both symptoms of attention-deficit/hyperactivity disorder (ADHD) and disruptive behavior disorders (DBD): that is, oppositional defiant disorder (ODD) and conduct disorder (CD) often comorbid with ADHD. The aim of this study was to test the association between COMT Val(158)Met polymorphism and the presence of DBD in children with ADHD (n = 516). Homozygous Val/Val children showed a higher prevalence of ADHD comorbid with DBD (χ(2) = 5.762; p = 0.016; OR = 1.58; CI(95%) = 1.07-2.35). Our findings replicate previous results and suggest a role for COMT in the etiology of DBD in children and adolescents with ADHD.

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Year:  2012        PMID： 22270685     DOI： 10.1007/s00702-012-0766-2

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  25 in total

Review 1.  A review of attention-deficit/hyperactivity disorder complicated by symptoms of oppositional defiant disorder or conduct disorder.

Authors:  Daniel F Connor; Jennifer Steeber; Keith McBurnett
Journal:  J Dev Behav Pediatr       Date:  2010-06       Impact factor: 2.225

2.  Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder.

Authors:  Anita Thapar; Kate Langley; Tom Fowler; Frances Rice; Darko Turic; Naureen Whittinger; John Aggleton; Marianne Van den Bree; Michael Owen; Michael O'Donovan
Journal:  Arch Gen Psychiatry       Date:  2005-11

3.  Smoking during pregnancy and attention-deficit/hyperactivity disorder, predominantly inattentive type: a case-control study.

Authors:  Marcelo Schmitz; Daniel Denardin; Tatiana Laufer Silva; Thiago Pianca; Mara Helena Hutz; Stephen Faraone; Luis Augusto Rohde
Journal:  J Am Acad Child Adolesc Psychiatry       Date:  2006-11       Impact factor: 8.829

4.  Fitting the pieces together: current research on the genetic basis of attention-deficit/hyperactivity disorder (ADHD).

Authors:  Evangelia Stergiakouli; Anita Thapar
Journal:  Neuropsychiatr Dis Treat       Date:  2010-09-07       Impact factor: 2.570

Review 5.  Is there a need to reformulate attention deficit hyperactivity disorder criteria in future nosologic classifications?

Authors:  Luis Augusto Rohde
Journal:  Child Adolesc Psychiatr Clin N Am       Date:  2008-04

6.  Structure of the rat catechol-O-methyltransferase gene: separate promoters are used to produce mRNAs for soluble and membrane-bound forms of the enzyme.

Authors:  J Tenhunen; M Salminen; A Jalanko; S Ukkonen; I Ulmanen
Journal:  DNA Cell Biol       Date:  1993-04       Impact factor: 3.311

7.  Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain.

Authors:  Jingshan Chen; Barbara K Lipska; Nader Halim; Quang D Ma; Mitsuyuki Matsumoto; Samer Melhem; Bhaskar S Kolachana; Thomas M Hyde; Mary M Herman; Jose Apud; Michael F Egan; Joel E Kleinman; Daniel R Weinberger
Journal:  Am J Hum Genet       Date:  2004-09-27       Impact factor: 11.025

Review 8.  Catechol-O-methyltransferase polymorphisms and some implications for cognitive therapeutics.

Authors:  Catherine M Diaz-Asper; Daniel R Weinberger; Terry E Goldberg
Journal:  NeuroRx       Date:  2006-01

9.  Genetic risk for conduct disorder symptom subtypes in an ADHD sample: specificity to aggressive symptoms.

Authors:  Michael C Monuteaux; Joseph Biederman; Alysa E Doyle; Eric Mick; Stephen V Faraone
Journal:  J Am Acad Child Adolesc Psychiatry       Date:  2009-07       Impact factor: 8.829

10.  Genotype link with extreme antisocial behavior: the contribution of cognitive pathways.

Authors:  Kate Langley; Jon Heron; Michael C O'Donovan; Michael J Owen; Anita Thapar
Journal:  Arch Gen Psychiatry       Date:  2010-12
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  5 in total

1.  COMT and DAT1 genes are associated with hyperactivity and inattention traits in the 1993 Pelotas Birth Cohort: evidence of sex-specific combined effect.

Authors:  Glaucia C Akutagava-Martins; Angelica Salatino-Oliveira; Christian Kieling; Julia P Genro; Guilherme V Polanczyk; Luciana Anselmi; Ana M B Menezes; Helen Gonçalves; Fernando C Wehrmeister; Fernando C Barros; Sidia M Callegari-Jacques; Luis A Rohde; Mara H Hutz
Journal:  J Psychiatry Neurosci       Date:  2016-10       Impact factor: 6.186

2.  Identifying mechanisms that underlie links between COMT genotype and aggression in male adolescents with ADHD.

Authors:  Stephanie H M van Goozen; Kate Langley; Clare Northover; Kelly Hubble; Katya Rubia; Karen Schepman; Michael C O'Donovan; Anita Thapar
Journal:  J Child Psychol Psychiatry       Date:  2015-09-23       Impact factor: 8.982

3.  COMT Val/Met and Psychopathic Traits in Children and Adolescents: A Systematic Review and New Evidence of a Developmental Trajectory toward Psychopathy.

Authors:  Tuana Kant; Emiko Koyama; Clement C Zai; Joseph H Beitchman; James L Kennedy
Journal:  Int J Mol Sci       Date:  2022-02-04       Impact factor: 5.923

4.  COMT and prenatal maternal smoking in associations with conduct problems and crime: the Pelotas 1993 birth cohort study.

Authors:  Angélica Salatino-Oliveira; Joseph Murray; Christian Kieling; Júlia Pasqualini Genro; Guilherme Polanczyk; Luciana Anselmi; Fernando Wehrmeister; Fernando C de Barros; Ana Maria Baptista Menezes; Luis Augusto Rohde; Mara Helena Hutz
Journal:  Sci Rep       Date:  2016-07-18       Impact factor: 4.379

Review 5.  The Role of the Catechol-o-Methyltransferase (COMT) GeneVal158Met in Aggressive Behavior, a Review of Genetic Studies.

Authors:  Arqam Qayyum; Clement C Zai; Yuko Hirata; Arun K Tiwari; Sheraz Cheema; Behdin Nowrouzi; Joseph H Beitchman; James L Kennedy
Journal:  Curr Neuropharmacol       Date:  2015       Impact factor: 7.363
  5 in total

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