Literature DB >> 22270059

Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms.

Zhao-Li Zhou1, Ya-Xi Yang, Jian Ding, Yuan-Chao Li, Ze-Hong Miao.   

Abstract

Triptolide, a principal bioactive ingredient of Tripterygium wilfordii Hook F, has attracted extensive exploration due to its unique structure of a diterpenoid triepoxide and multiple biological activities. This review will focus on the structural modifications, structure-activity relationships, pharmacology, and clinical development of triptolide in the last forty years.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22270059     DOI： 10.1039/c2np00088a

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  77 in total

Review 1.  Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates.

Authors:  Zhiyan Xiao; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  Med Res Rev       Date:  2015-09-11       Impact factor: 12.944

2.  Triptolide reduces the viability of osteosarcoma cells by reducing MKP-1 and Hsp70 expression.

Authors:  Lei Zhao; B O Jiang; Dong Wang; Wei Liu; Huawu Zhang; Weisheng Liu; Zhen Qiu
Journal:  Exp Ther Med       Date:  2016-03-15       Impact factor: 2.447

3.  Biosynthesis of Diterpenoids in Tripterygium Adventitious Root Cultures.

Authors:  Fainmarinat S Inabuy; Justin T Fischedick; Iris Lange; Michael Hartmann; Narayanan Srividya; Amber N Parrish; Meimei Xu; Reuben J Peters; B Markus Lange
Journal:  Plant Physiol       Date:  2017-07-27       Impact factor: 8.340

4.  Correspondence.

Authors:  Yan-Jie Huang; Xiao-Qing Yang; Wen-Sheng Zhai; Xian-Qing Ren; Yuan Sun; Ying Ding
Journal:  World J Pediatr       Date:  2016-08       Impact factor: 2.764

5.  Triptolide and celastrol loaded silk fibroin nanoparticles show synergistic effect against human pancreatic cancer cells.

Authors:  Baoyue Ding; Md Arif Wahid; Zhijun Wang; Chen Xie; Arvind Thakkar; Sunil Prabhu; Jeffrey Wang
Journal:  Nanoscale       Date:  2017-08-17       Impact factor: 7.790

Review 6.  Chalcone: A Privileged Structure in Medicinal Chemistry.

Authors:  Chunlin Zhuang; Wen Zhang; Chunquan Sheng; Wannian Zhang; Chengguo Xing; Zhenyuan Miao
Journal:  Chem Rev       Date:  2017-05-10       Impact factor: 60.622

7.  Lipophilic stinging nettle extracts possess potent anti-inflammatory activity, are not cytotoxic and may be superior to traditional tinctures for treating inflammatory disorders.

Authors:  Tyler A Johnson; Johann Sohn; Wayne D Inman; Leonard F Bjeldanes; Keith Rayburn
Journal:  Phytomedicine       Date:  2012-10-23       Impact factor: 5.340

8.  Accurate mass-time tag library for LC/MS-based metabolite profiling of medicinal plants.

Authors:  Daniel J Cuthbertson; Sean R Johnson; Jasenka Piljac-Žegarac; Julia Kappel; Sarah Schäfer; Matthias Wüst; Raymond E B Ketchum; Rodney B Croteau; Joaquim V Marques; Laurence B Davin; Norman G Lewis; Megan Rolf; Toni M Kutchan; D Doel Soejarto; B Markus Lange
Journal:  Phytochemistry       Date:  2013-04-16       Impact factor: 4.072

Review 9.  Newly discovered angiogenesis inhibitors and their mechanisms of action.

Authors:  Ze-hong Miao; Jian-ming Feng; Jian Ding
Journal:  Acta Pharmacol Sin       Date:  2012-08-27       Impact factor: 6.150

10.  Triptolide-mediated inhibition of interferon signaling enhances vesicular stomatitis virus-based oncolysis.

Authors:  Fethia Ben Yebdri; Julien Van Grevenynghe; Vera A Tang; Marie-Line Goulet; Jian Hui Wu; David F Stojdl; John Hiscott; Rongtuan Lin
Journal:  Mol Ther       Date:  2013-08-28       Impact factor: 11.454
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.