Literature DB >> 2226872

Generation of human endothelin by cathepsin E.

W E Lees1, S Kalinka, J Meech, S J Capper, N D Cook, J Kay.   

Abstract

Highly-purified cathepsin D processed human big endothelin1-38 into endothelin-like fragments but did not appear to generate endothelin1-21 under the conditions employed. By contrast, human cathepsin E specifically cleaved human big endothelin into endothelin1-21 and the C-terminal fragment under identical conditions but did not degrade either product further.

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Year:  1990        PMID： 2226872     DOI： 10.1016/0014-5793(90)81060-2

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  7 in total

1.  Kinetic parameters for the generation of endothelins-1,-2 and -3 by human cathepsin E.

Authors:  P S Robinson; W E Lees; J Kay; N D Cook
Journal:  Biochem J       Date:  1992-06-01       Impact factor: 3.857

2.  Crystal structure of human pepsin and its complex with pepstatin.

Authors:  M Fujinaga; M M Chernaia; N I Tarasova; S C Mosimann; M N James
Journal:  Protein Sci       Date:  1995-05       Impact factor: 6.725

3.  Biochemical characterization and structural modeling of human cathepsin E variant 2 in comparison to the wild-type protein.

Authors:  Vida Puizdar; Tajana Zajc; Eva Zerovnik; Miha Renko; Ursula Pieper; Narayanan Eswar; Andrej Sali; Iztok Dolenc; Vito Turk
Journal:  Biol Chem       Date:  2012-03       Impact factor: 3.915

4.  The two-step conversion of big endothelin 1 to endothelin 1 and degradation of endothelin 1 by subcellular fractions from human polymorphonuclear leukocytes.

Authors:  S Kaw; M Hecker; J R Vane
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-01       Impact factor: 11.205

5.  Endothelin excretion during ketoacidosis does not correlate with tubular dysfunction.

Authors:  I Máttyus; M Miltényi; L B Zimmerhackl; A Schwarz; M Hentschel; M Brandis; T Tulassay
Journal:  Pediatr Nephrol       Date:  1994-06       Impact factor: 3.714

6.  Mouse connective tissue mast cell proteases tryptase and carboxypeptidase A3 play protective roles in itch induced by endothelin-1.

Authors:  Elín I Magnúsdóttir; Mirjana Grujic; Jessica Bergman; Gunnar Pejler; Malin C Lagerström
Journal:  J Neuroinflammation       Date:  2020-04-22       Impact factor: 8.322

7.  Human breast cancer cells contain a phosphoramidon-sensitive metalloproteinase which can process exogenous big endothelin-1 to endothelin-1: a proposed mitogen for human breast fibroblasts.

Authors:  K V Patel; M P Schrey
Journal:  Br J Cancer       Date:  1995-03       Impact factor: 7.640
  7 in total

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