OBJECTIVE: To investigate the rate of neural tube defects (NTDs) and their relation to gender, maternal age, consanguineous marriage, season, and drug consumption in Birjand, Iran. METHODS: This research was carried out on 16,785 live or stillborn newborns in Birjand, Iran from April 1997 to December 2001. RESULTS: The rate of NTDs was 2.97 per 1000. This rate was 1.97 per 1000 in males, and 3.55 per 1000 in females. The rate of anencephaly was 1.37 per 1000, and spina bifida was 0.88 per 1000. We found that 32% of mothers with affected newborns had taken drugs during the first trimester of pregnancy, 90% of mothers did not consume folate before and during the first trimester, and 54% of parents had consanguineous marriage. CONCLUSION: We concluded that folate deficiency, usage of drugs during pregnancy, and consanguineous marriage may play a role of predisposition to NTD.
OBJECTIVE: To investigate the rate of neural tube defects (NTDs) and their relation to gender, maternal age, consanguineous marriage, season, and drug consumption in Birjand, Iran. METHODS: This research was carried out on 16,785 live or stillborn newborns in Birjand, Iran from April 1997 to December 2001. RESULTS: The rate of NTDs was 2.97 per 1000. This rate was 1.97 per 1000 in males, and 3.55 per 1000 in females. The rate of anencephaly was 1.37 per 1000, and spina bifida was 0.88 per 1000. We found that 32% of mothers with affected newborns had taken drugs during the first trimester of pregnancy, 90% of mothers did not consume folate before and during the first trimester, and 54% of parents had consanguineous marriage. CONCLUSION: We concluded that folate deficiency, usage of drugs during pregnancy, and consanguineous marriage may play a role of predisposition to NTD.
Authors: Callie A M Atta; Kirsten M Fiest; Alexandra D Frolkis; Nathalie Jette; Tamara Pringsheim; Christine St Germaine-Smith; Thilinie Rajapakse; Gilaad G Kaplan; Amy Metcalfe Journal: Am J Public Health Date: 2015-11-12 Impact factor: 9.308
Authors: Soudabeh Vatankhah; Mina Jalilvand; Samaneh Sarkhosh; Mina Azarmi; Mohammad Mohseni Journal: Iran J Public Health Date: 2017-06 Impact factor: 1.429
Authors: Leonor Maria Pacheco Santos; Roberto Carlos Reyes Lecca; Juan Jose Cortez-Escalante; Mauro Niskier Sanchez; Humberto Gabriel Rodrigues Journal: Bull World Health Organ Date: 2015-10-27 Impact factor: 9.408
Authors: Ibrahim Zaganjor; Ahlia Sekkarie; Becky L Tsang; Jennifer Williams; Hilda Razzaghi; Joseph Mulinare; Joseph E Sniezek; Michael J Cannon; Jorge Rosenthal Journal: PLoS One Date: 2016-04-11 Impact factor: 3.240