| Literature DB >> 22265568 |
Philip R Miller1, Shelby A Skoog, Thayne L Edwards, Deanna M Lopez, David R Wheeler, Dulce C Arango, Xiaoyin Xiao, Susan M Brozik, Joseph Wang, Ronen Polsky, Roger J Narayan.
Abstract
The development of a microneedle-based biosensor array for multiplexed in situ detection of exercise-induced metabolic acidosis, tumor microenvironment, and other variations in tissue chemistry is described. Simultaneous and selective amperometric detection of pH, glucose, and lactate over a range of physiologically relevant concentrations in complex media is demonstrated. Furthermore, materials modified with a cell-resistant (Lipidure(®)) coating were shown to inhibit macrophage adhesion; no signs of coating delamination were noted over a 48-h period.Entities:
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Year: 2011 PMID： 22265568 PMCID： PMC3266534 DOI： 10.1016/j.talanta.2011.11.046
Source DB: PubMed Journal: Talanta ISSN： 0039-9140 Impact factor: 6.057