Charlotte Eklund1, Peter Friberg, Li-Ming Gan. 1. Department of Clinical Physiology, Sahlgrenska University Hospital, S-41345 Gothenburg, Sweden. charlotte.eklund@vgregion.se
Abstract
OBJECTIVE: The radial artery wall structure can be measured with non-invasive very high-resolution ultrasound with great feasibility and high accuracy. In the present study, we aim to explore clinical correlates of radial artery intima-media thickness (rIMT), in a relatively large patient cohort with suspected coronary artery disease, and further compare those to common carotid artery IMT (cIMT) that is an accepted surrogate marker of atherosclerosis. METHODS: Four hundred and sixteen patients referred to myocardial perfusion scintigram (MPS) were recruited, and cIMT and rIMT were scanned using conventional and very high-resolution ultrasound (55 MHz transducer), respectively. A number of plasma biomarkers were also measured. RESULTS: Both cIMT and rIMT were similarly correlated with disease history, MPS-verified ischemia, carotid plaque burden, and lipid status. Repeated measurement of rIMT showed acceptable variability. CONCLUSION: Radial artery IMT may constitute a novel feasible imaging biomarker for systemic atherosclerosis burden, which may be used in future imaging trials to evaluate, e.g. anti-atherosclerotic treatments. Copyright Â
OBJECTIVE: The radial artery wall structure can be measured with non-invasive very high-resolution ultrasound with great feasibility and high accuracy. In the present study, we aim to explore clinical correlates of radial artery intima-media thickness (rIMT), in a relatively large patient cohort with suspected coronary artery disease, and further compare those to common carotid artery IMT (cIMT) that is an accepted surrogate marker of atherosclerosis. METHODS: Four hundred and sixteen patients referred to myocardial perfusion scintigram (MPS) were recruited, and cIMT and rIMT were scanned using conventional and very high-resolution ultrasound (55 MHz transducer), respectively. A number of plasma biomarkers were also measured. RESULTS: Both cIMT and rIMT were similarly correlated with disease history, MPS-verified ischemia, carotid plaque burden, and lipid status. Repeated measurement of rIMT showed acceptable variability. CONCLUSION: Radial artery IMT may constitute a novel feasible imaging biomarker for systemic atherosclerosis burden, which may be used in future imaging trials to evaluate, e.g. anti-atherosclerotic treatments. Copyright Â
Authors: Johnny Km Sundholm; Linda Litwin; Kristiina Rönö; Saila B Koivusalo; Johan G Eriksson; Taisto Sarkola Journal: Diab Vasc Dis Res Date: 2022 May-Jun Impact factor: 3.541
Authors: Scott T Chiesa; Marietta Charakida; Georgios Georgiopoulos; Frida Dangardt; Kaitlin H Wade; Alicja Rapala; Devina J Bhowruth; Helen C Nguyen; Vivek Muthurangu; Rukshana Shroff; George Davey Smith; Debbie A Lawlor; Naveed Sattar; Nicholas J Timpson; Alun D Hughes; John E Deanfield Journal: JACC Cardiovasc Imaging Date: 2019-10-11
Authors: Damilola D Adingupu; Helena U Westergren; Santosh Dahgam; Ann-Cathrine Jönsson-Rylander; Juuso Blomster; Per Albertsson; Elmir Omerovic; Sara Svedlund; Li-Ming Gan Journal: Oncotarget Date: 2017-06-16