Literature DB >> 22263787

Anticancer activity and anti-inflammatory studies of 5-aryl-1,4-benzodiazepine derivatives.

Cortez-Maya Sandra1, Cortes Cortes Eduardo, Hernandez-Ortega Simon, Ramirez Apan Teresa, Nieto Camacho Antonio, Irina V Lijanova, Martinez-Garcia Marcos.   

Abstract

A series of 5-aryl-1,4-benzodiazepines with chloro- or fluoro-substituents in the second ring have been synthesized and their anti-inflammatory, myeloperoxidase and anticancer properties studied. The synthesized compounds showed potential anti-inflammatory and anticancer activities, which were enhanced in the presence of a chloro-substituent in the second ring of the 5-aryl-1,4- benzodiazepine.

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Year:  2012        PMID： 22263787     DOI： 10.2174/187152012800617713

Source DB:  PubMed          Journal:  Anticancer Agents Med Chem        ISSN： 1871-5206            Impact factor:   2.505


  4 in total

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Journal:  Molecules       Date:  2022-06-10       Impact factor: 4.927

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Journal:  Chem Cent J       Date:  2015-04-08       Impact factor: 4.215

3.  Iminostilbene, a novel small-molecule modulator of PKM2, suppresses macrophage inflammation in myocardial ischemia-reperfusion injury.

Authors:  Shan Lu; Yu Tian; Yun Luo; Xudong Xu; Wenxiu Ge; Guibo Sun; Xiaobo Sun
Journal:  J Adv Res       Date:  2020-09-09       Impact factor: 10.479

4.  Crystal structure and Hirshfeld surface analysis of 2-azido-N-(4-fluoro-phen-yl)acetamide.

Authors:  Mohcine Missioui; Walid Guerrab; Abdulsalam Alsubari; Joel T Mague; Youssef Ramli
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2022-07-29
  4 in total

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