Literature DB >> 22260294

Amyrisins A-C, O-prenylated flavonoids from Amyris madrensis.

Jiangnan Peng1, Rachel M Hartley, Gary A Fest, Susan L Mooberry.   

Abstract

Three new O-prenylated flavonoids, amyrisins A-C (1-3), were isolated from the leaves and twigs of Amyris madrensis, along with the known compound polygamain (4). The structures of 1-3 were elucidated on the basis of the analysis of spectroscopic data interpretation. Amyrisins B (2) and C (3) showed moderate cytotoxicity against PC-3 and DU 145 prostate cancer cells with IC(50) values of 17.5 and 23 μM, respectively, while amyrisin A (1) did not show any cytotoxicity at the highest concentration tested, 50 μM. Polygamain (4) exhibited potent antiproliferative and microtubule-depolymerizing activities.

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Year:  2012        PMID： 22260294      PMCID： PMC3311741          DOI： 10.1021/np200796e

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  7 in total

1.  Polygamain, a new microtubule depolymerizing agent that occupies a unique pharmacophore in the colchicine site.

Authors:  R M Hartley; J Peng; G A Fest; S Dakshanamurthy; D E Frantz; M L Brown; S L Mooberry
Journal:  Mol Pharmacol       Date:  2011-12-14       Impact factor: 4.436

2.  Identification and biological activities of new taccalonolide microtubule stabilizers.

Authors:  Jiangnan Peng; April L Risinger; Gary A Fest; Evelyn M Jackson; Gregory Helms; Lisa A Polin; Susan L Mooberry
Journal:  J Med Chem       Date:  2011-08-11       Impact factor: 7.446

3.  Evelynin, a cytotoxic benzoquinone-type Retro-dihydrochalcone from Tacca chantrieri.

Authors:  Jiangnan Peng; Evelyn M Jackson; David J Babinski; April L Risinger; Gregory Helms; Doug E Frantz; Susan L Mooberry
Journal:  J Nat Prod       Date:  2010-09-24       Impact factor: 4.050

4.  New colorimetric cytotoxicity assay for anticancer-drug screening.

Authors:  P Skehan; R Storeng; D Scudiero; A Monks; J McMahon; D Vistica; J T Warren; H Bokesch; S Kenney; M R Boyd
Journal:  J Natl Cancer Inst       Date:  1990-07-04       Impact factor: 13.506

5.  Taccalonolides E and A: Plant-derived steroids with microtubule-stabilizing activity.

Authors:  Tina L Tinley; Deborah A Randall-Hlubek; Rachel M Leal; Evelyn M Jackson; James W Cessac; James C Quada; Thomas K Hemscheidt; Susan L Mooberry
Journal:  Cancer Res       Date:  2003-06-15       Impact factor: 12.701

6.  The taccalonolides: microtubule stabilizers that circumvent clinically relevant taxane resistance mechanisms.

Authors:  April L Risinger; Evelyn M Jackson; Lisa A Polin; Gregory L Helms; Desiree A LeBoeuf; Patrick A Joe; Elizabeth Hopper-Borge; Richard F Ludueña; Gary D Kruh; Susan L Mooberry
Journal:  Cancer Res       Date:  2008-11-01       Impact factor: 12.701

7.  Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining.

Authors:  A Krishan
Journal:  J Cell Biol       Date:  1975-07       Impact factor: 10.539
  7 in total
  3 in total

1.  Texas Native Plants Yield Compounds with Cytotoxic Activities against Prostate Cancer Cells.

Authors:  Corena V Shaffer; Shengxin Cai; Jiangnan Peng; Andrew J Robles; Rachel M Hartley; Douglas R Powell; Lin Du; Robert H Cichewicz; Susan L Mooberry
Journal:  J Nat Prod       Date:  2016-01-19       Impact factor: 4.050

2.  Neougonin A Inhibits Lipopolysaccharide-Induced Inflammatory Responses via Downregulation of the NF-kB Signaling Pathway in RAW 264.7 Macrophages.

Authors:  Lang Cao; Rongtao Li; Xuanqin Chen; Yong Xue; Dan Liu
Journal:  Inflammation       Date:  2016-12       Impact factor: 4.092

3.  Melampodium leucanthum, a source of cytotoxic sesquiterpenes with antimitotic activities.

Authors:  Andrew J Robles; Jiangnan Peng; Rachel M Hartley; Brigette Lee; Susan L Mooberry
Journal:  J Nat Prod       Date:  2015-02-16       Impact factor: 4.050
  3 in total

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