Literature DB >> 22259787

CD5-negative blastoid variant mantle cell lymphoma with complex CCND1/IGH and MYC aberrations.

Yoonmi Seok1, Juwon Kim, Jong Rak Choi, Yu Ri Kim, Seo-Jin Park, Sue Jung Kim, Jaewoo Song, Kyung-A Lee.   

Abstract

The coexistence of CCND1/IGH and MYC rearrangements in mantle cell lymphoma (MCL) is a rare finding associated with a very poor prognosis. In this study, a patient with blastoid variant (MCL) is reported. The disease was clinically aggressive and refractory to chemotherapy, and the patient only survived for 1 month following diagnosis. Conventional cytogenetic study, FISH, and multicolor FISH (mFISH) demonstrated the involvement of the BCL1/CCND1 locus in a complex translocation, t(3;11)(q25;p15)t(11;14)(q13;q32). In addition, subclonal abnormalities in the 8q24 region, manifested as a t(8;14)(q24;q32)/MYC rearrangement, were identified. To the best of our knowledge, this is the first MCL case in Korea bearing these complex genomic aberrations.

Entities:  

Keywords:  CCND1; MYC; Mantle cell lymphoma

Mesh：

Substances：

Year:  2011        PMID： 22259787      PMCID： PMC3255497          DOI： 10.3343/alm.2012.32.1.95

Source DB:  PubMed          Journal:  Ann Lab Med        ISSN： 2234-3806            Impact factor:   3.464


  19 in total

1.  8q24 translocations in blastic transformation of mantle cell lymphoma.

Authors:  W Y Au; D E Horsman; D S Viswanatha; J M Connors; R J Klasa; R D Gascoyne
Journal:  Haematologica       Date:  2000-11       Impact factor: 9.941

Review 2.  Molecular basis of mantle cell lymphoma.

Authors:  Francesco Bertoni; Emanuele Zucca; Finbarr E Cotter
Journal:  Br J Haematol       Date:  2004-01       Impact factor: 6.998

3.  Cytogenetic analysis in mantle cell lymphoma: a review of 214 cases.

Authors:  Wing Y Au; Randy D Gascoyne; David S Viswanatha; Joseph M Connors; Richard J Klasa; Douglas E Horsman
Journal:  Leuk Lymphoma       Date:  2002-04

4.  Molecular cytogenetic study of a mantle cell lymphoma with a complex translocation involving the CCND1 (11q13) region.

Authors:  Sonia Maravelaki; Anna Burford; Andrew Wotherspoon; Rajeev Joshi; Estela Matutes; Daniel Catovsky; Vasantha Brito-Babapulle
Journal:  Cancer Genet Cytogenet       Date:  2004-10-01

Review 5.  The impact of MYC expression in lymphoma biology: beyond Burkitt lymphoma.

Authors:  Sonali M Smith; John Anastasi; Kenneth S Cohen; Lucy A Godley
Journal:  Blood Cells Mol Dis       Date:  2010-09-06       Impact factor: 3.039

6.  An unusual case of leukemic mantle cell lymphoma with a blastoid component showing loss of CD5 and aberrant expression of CD10.

Authors:  William G Morice; Janice M Hodnefield; Paul J Kurtin; Curtis A Hanson
Journal:  Am J Clin Pathol       Date:  2004-07       Impact factor: 2.493

7.  Identification of new nonrandom translocations in multiple myeloma with multicolor spectral karyotyping.

Authors:  J R Sawyer; J L Lukacs; N Munshi; K R Desikan; S Singhal; J Mehta; D Siegel; J Shaughnessy; B Barlogie
Journal:  Blood       Date:  1998-12-01       Impact factor: 22.113

8.  Coexistence of BCL1/CCND1 and CMYC aberrations in blastoid mantle cell lymphoma: a rare finding associated with very poor outcome.

Authors:  L Michaux; I Wlodarska; I Theate; M Stul; J-M Scheiff; V Deneys; A Ferrant; A Hagemeijer
Journal:  Ann Hematol       Date:  2004-05-12       Impact factor: 3.673

9.  Blastoid mantle cell lymphoma: evidence for nonrandom cytogenetic abnormalities additional to t(11;14) and generation of a mouse model.

Authors:  R M'kacher; F Farace; A Bennaceur-Griscelli; D Violot; B Clausse; J Dossou; A Valent; C Parmentier; V Ribrag; J Bosq; P Carde; A G Turhan; A Bernheim
Journal:  Cancer Genet Cytogenet       Date:  2003-05

10.  CD23 expression in mantle cell lymphoma: clinicopathologic features of 18 cases.

Authors:  Ellen Schlette; Kai Fu; L Jeffrey Medeiros
Journal:  Am J Clin Pathol       Date:  2003-11       Impact factor: 2.493
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  3 in total

Review 1.  Double-hit mantle cell lymphoma with MYC gene rearrangement or amplification: a report of four cases and review of the literature.

Authors:  Reza Setoodeh; Stuart Schwartz; Peter Papenhausen; Ling Zhang; Elizabeth M Sagatys; Lynn C Moscinski; Haipeng Shao
Journal:  Int J Clin Exp Pathol       Date:  2013-01-15

2.  Blastoid variant mantle cell lymphoma with complex karyotype including 11q duplication.

Authors:  Ozge Ozer; Selami Koçak Toprak; Enver Ote; Zerrin Yılmaz; Feride Iffet Sahin
Journal:  Turk J Haematol       Date:  2014-09-05       Impact factor: 1.831

3.  High incidence of MYC and BCL2 abnormalities in mantle cell lymphoma, although only MYC abnormality predicts poor survival.

Authors:  Shuhua Yi; Dehui Zou; Chengwen Li; Shizhen Zhong; Weiwei Chen; Zengjun Li; Wenjie Xiong; Wei Liu; Enbin Liu; Rui Cui; Kun Ru; Peihong Zhang; Yan Xu; Gang An; Rui Lv; Junyuan Qi; Jianxiang Wang; Tao Cheng; Lugui Qiu
Journal:  Oncotarget       Date:  2015-12-08
  3 in total

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