Literature DB >> 15138714

Coexistence of BCL1/CCND1 and CMYC aberrations in blastoid mantle cell lymphoma: a rare finding associated with very poor outcome.

L Michaux1, I Wlodarska, I Theate, M Stul, J-M Scheiff, V Deneys, A Ferrant, A Hagemeijer.   

Abstract

A patient with mantle cell lymphoma (MCL) of the pleomorphic blastoid subtype is reported. The disease was clinically aggressive and refractory to chemotherapy, and the patient survived only 2 months. Cytogenetically, a t(11;19;14)(q13;q13;q32) was found. Fluorescent in situ hybridization (FISH) and molecular analyses demonstrated involvement of the BCL1/CCND1 locus in a three-way translocation. In addition, subclonal abnormalities of the region 8q24 manifested either as a t(8;22)(q24;q11)/CMYC rearrangement or trisomy 8 were identified. The pathogenetic impact of this very uncommon association of BCL1/CCND1 and CMYC rearrangements in MCL is discussed and the literature is reviewed.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15138714     DOI： 10.1007/s00277-004-0879-2

Source DB:  PubMed          Journal:  Ann Hematol        ISSN： 0939-5555            Impact factor:   3.673


  7 in total

Review 1.  Mantle cell lymphoma--a spectrum from indolent to aggressive disease.

Authors:  Birgitta Sander; Leticia Quintanilla-Martinez; German Ott; Luc Xerri; Isinsu Kuzu; John K C Chan; Steven H Swerdlow; Elias Campo
Journal:  Virchows Arch       Date:  2015-08-23       Impact factor: 4.064

Review 2.  Reviewing once more the c-myc and Ras collaboration: converging at the cyclin D1-CDK4 complex and challenging basic concepts of cancer biology.

Authors:  Chenguang Wang; Michael P Lisanti; D Joshua Liao
Journal:  Cell Cycle       Date:  2011-01-01       Impact factor: 4.534

3.  CD5-negative blastoid variant mantle cell lymphoma with complex CCND1/IGH and MYC aberrations.

Authors:  Yoonmi Seok; Juwon Kim; Jong Rak Choi; Yu Ri Kim; Seo-Jin Park; Sue Jung Kim; Jaewoo Song; Kyung-A Lee
Journal:  Ann Lab Med       Date:  2011-12-20       Impact factor: 3.464

4.  Silibinin suppresses spontaneous tumorigenesis in APC min/+ mouse model by modulating beta-catenin pathway.

Authors:  Subapriya Rajamanickam; Manjinder Kaur; Balaiya Velmurugan; Rana P Singh; Rajesh Agarwal
Journal:  Pharm Res       Date:  2009-09-25       Impact factor: 4.200

Review 5.  Double-hit mantle cell lymphoma with MYC gene rearrangement or amplification: a report of four cases and review of the literature.

Authors:  Reza Setoodeh; Stuart Schwartz; Peter Papenhausen; Ling Zhang; Elizabeth M Sagatys; Lynn C Moscinski; Haipeng Shao
Journal:  Int J Clin Exp Pathol       Date:  2013-01-15

Review 6.  Smoldering mantle cell lymphoma.

Authors:  Haige Ye; Aakash Desai; Dongfeng Zeng; Krystle Nomie; Jorge Romaguera; Makhdum Ahmed; Michael L Wang
Journal:  J Exp Clin Cancer Res       Date:  2017-12-15

Review 7.  The Role of c-MYC in B-Cell Lymphomas: Diagnostic and Molecular Aspects.

Authors:  Lynh Nguyen; Peter Papenhausen; Haipeng Shao
Journal:  Genes (Basel)       Date:  2017-04-05       Impact factor: 4.096
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.