OBJECTIVES: There is no literature available on the performance of cystatin C in Chronic Kidney Disease (CKD) patients of Indian population based on age group. Hence, this study is aimed to compare the diagnostic performance of serum cystatin C and creatinine with measured glomerular filtration rate (GFR) and estimated GFR (eGFR) in subjects of Indian origin. METHODS: The study was carried out at Tiruchirappalli, South India during the period of September 2010 to march 2011. One hundred and six CKD patients (82 males, 24 females) were enrolled and categorized into three groups based on age. The eGFR was calculated using Cockcroft-Gault (CG) and Modification of Diet in Renal Disease (MDRD) formulae. Serum cystatin C was measured with a particle-enhanced nephelometric immunoassay (PENIA) method. GFR was measured using (99m)T(C) - diethylene triamine penta aceticacid (DTPA) renal scan method. RESULTS: Serum cystatin C showed significant correlation with measured GFR in all the three groups (r=-0.9735, r=-0.8975 and r=-0.7994 respectively) than serum creatinine (r=-0.7380, r=-0.6852 and r=-0.5127 respectively). CONCLUSION: Serum cystatin C showed a high correlation with measured GFR in young and older patients with CKD than creatinine. Thus, cystatin C is a good alternative marker to creatinine in CKD patients.
OBJECTIVES: There is no literature available on the performance of cystatin C in Chronic Kidney Disease (CKD) patients of Indian population based on age group. Hence, this study is aimed to compare the diagnostic performance of serum cystatin C and creatinine with measured glomerular filtration rate (GFR) and estimated GFR (eGFR) in subjects of Indian origin. METHODS: The study was carried out at Tiruchirappalli, South India during the period of September 2010 to march 2011. One hundred and six CKDpatients (82 males, 24 females) were enrolled and categorized into three groups based on age. The eGFR was calculated using Cockcroft-Gault (CG) and Modification of Diet in Renal Disease (MDRD) formulae. Serum cystatin C was measured with a particle-enhanced nephelometric immunoassay (PENIA) method. GFR was measured using (99m)T(C) - diethylene triamine penta aceticacid (DTPA) renal scan method. RESULTS: Serum cystatin C showed significant correlation with measured GFR in all the three groups (r=-0.9735, r=-0.8975 and r=-0.7994 respectively) than serum creatinine (r=-0.7380, r=-0.6852 and r=-0.5127 respectively). CONCLUSION: Serum cystatin C showed a high correlation with measured GFR in young and older patients with CKD than creatinine. Thus, cystatin C is a good alternative marker to creatinine in CKDpatients.
Authors: A Prigent; P Cosgriff; G F Gates; G Granerus; E J Fine; K Itoh; M Peters; A Piepsz; M Rehling; M Rutland; A Taylor Journal: Semin Nucl Med Date: 1999-04 Impact factor: 4.446
Authors: Shelagh E O'Riordan; Michelle C Webb; Helen J Stowe; David E Simpson; Madhu Kandarpa; Anthony J Coakley; David J Newman; Jean A Saunders; Edmund J Lamb Journal: Ann Clin Biochem Date: 2003-11 Impact factor: 2.057
Authors: Nik-Rosmawati Nik Husain; Suhaily Mohd Hairon; Rehanah Mohd Zain; Mujahid Bakar; Tee Get Bee; Mohamed Saat Ismail Journal: Oman Med J Date: 2020-03-19