BACKGROUND/ OBJECTIVES: To provide a detailed lipid profile of a European adolescent population considering age, gender, biological maturity, body mass index (BMI), fat mass (FM) and percentage body fat (BF). SUBJECTS/ METHODS: Within Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA), a cross-sectional study was conducted to determine fasting serum concentrations of lipids, lipoproteins and apolipoproteins in 1076 adolescents aged 12.5-17.49 years from ten European centres. RESULTS: All serum lipid concentrations were significantly higher in girls than in boys. In boys, age was negatively correlated with high-density lipoprotein (HDL)-cholesterol and total cholesterol (TC), and positively associated with triacylglycerides (TAG) (P < 0.01) whereas no significant associations were observed in girls. Biological maturity was negatively associated with TC, HDL-, low-density lipoprotein (LDL)- and non-HDL cholesterol in boys (all P<0.05) and negatively correlated with HDL-cholesterol in girls (P<0.05). BMI, FM and BF were significantly correlated with HDL-cholesterol, LDL-cholesterol, non-HDL cholesterol, apolipoprotein (apo) A1, apoB and TAG in both boys and girls. CONCLUSIONS: The lipid profile in adolescents is strongly determined by gender. Biological maturity, FM and percentage BF contribute to the variance in lipid concentrations and should be considered in future evaluations of lipid status.
BACKGROUND/ OBJECTIVES: To provide a detailed lipid profile of a European adolescent population considering age, gender, biological maturity, body mass index (BMI), fat mass (FM) and percentage body fat (BF). SUBJECTS/ METHODS: Within Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA), a cross-sectional study was conducted to determine fasting serum concentrations of lipids, lipoproteins and apolipoproteins in 1076 adolescents aged 12.5-17.49 years from ten European centres. RESULTS: All serum lipid concentrations were significantly higher in girls than in boys. In boys, age was negatively correlated with high-density lipoprotein (HDL)-cholesterol and total cholesterol (TC), and positively associated with triacylglycerides (TAG) (P < 0.01) whereas no significant associations were observed in girls. Biological maturity was negatively associated with TC, HDL-, low-density lipoprotein (LDL)- and non-HDL cholesterol in boys (all P<0.05) and negatively correlated with HDL-cholesterol in girls (P<0.05). BMI, FM and BF were significantly correlated with HDL-cholesterol, LDL-cholesterol, non-HDL cholesterol, apolipoprotein (apo) A1, apoB and TAG in both boys and girls. CONCLUSIONS: The lipid profile in adolescents is strongly determined by gender. Biological maturity, FM and percentage BF contribute to the variance in lipid concentrations and should be considered in future evaluations of lipid status.
Authors: Sally Sultan; Michael Dowling; Adam Kirton; Gabrielle DeVeber; Alexandra Linds; Mitchell S V Elkind Journal: Pediatr Neurol Date: 2017-10-10 Impact factor: 3.372
Authors: S De Henauw; N Michels; K Vyncke; A Hebestreit; P Russo; T Intemann; J Peplies; A Fraterman; G Eiben; M de Lorgeril; M Tornaritis; D Molnar; T Veidebaum; W Ahrens; L A Moreno Journal: Int J Obes (Lond) Date: 2014-09 Impact factor: 5.095
Authors: Susan Ellul; Melissa Wake; Susan A Clifford; Katherine Lange; Peter Würtz; Markus Juonala; Terence Dwyer; John B Carlin; David P Burgner; Richard Saffery Journal: BMJ Open Date: 2019-07-04 Impact factor: 2.692