BACKGROUND: Chloral hydrate (CH) is safe and effective for sedation of suitable children. OBJECTIVE: The purpose of this study was to assess whether adequate sedation is achieved with reduced CH doses. MATERIALS AND METHODS: We retrospectively recorded outpatient CH sedations over 1 year. We defined standard doses of CH as 50 mg/kg (infants) and 75 mg/kg (children >1 year). A reduced dose was defined as at least 20% lower than the standard dose. RESULTS: In total, 653 children received CH sedation (age, 1 month-3 years 10 months), 42% were given a reduced initial dose. Augmentation dose was required in 10.9% of all children, and in a higher proportion of children >1 year (15.7%) compared to infants (5.7%; P < 0.001). Sedation was successful in 96.7%, and more frequently successful in infants (98.3%) than children >1 year (95.3%; P = 0.03). A reduced initial dose had no negative effect on outcome (P = 0.19) or time to sedation. No significant complications were seen. CONCLUSION: We advocate sedation with reduced CH doses (40 mg/kg for infants; 60 mg/kg for children >1 year of age) for outpatient imaging procedures when the child is judged to be quiet or sleepy on arrival.
BACKGROUND:Chloral hydrate (CH) is safe and effective for sedation of suitable children. OBJECTIVE: The purpose of this study was to assess whether adequate sedation is achieved with reduced CH doses. MATERIALS AND METHODS: We retrospectively recorded outpatientCH sedations over 1 year. We defined standard doses of CH as 50 mg/kg (infants) and 75 mg/kg (children >1 year). A reduced dose was defined as at least 20% lower than the standard dose. RESULTS: In total, 653 children received CH sedation (age, 1 month-3 years 10 months), 42% were given a reduced initial dose. Augmentation dose was required in 10.9% of all children, and in a higher proportion of children >1 year (15.7%) compared to infants (5.7%; P < 0.001). Sedation was successful in 96.7%, and more frequently successful in infants (98.3%) than children >1 year (95.3%; P = 0.03). A reduced initial dose had no negative effect on outcome (P = 0.19) or time to sedation. No significant complications were seen. CONCLUSION: We advocate sedation with reduced CH doses (40 mg/kg for infants; 60 mg/kg for children >1 year of age) for outpatient imaging procedures when the child is judged to be quiet or sleepy on arrival.
Authors: Mark A Fogel; Paul M Weinberg; Elicia Parave; Christine Harris; Lisa Montenegro; Matthew A Harris; Mikael Concepcion Journal: J Pediatr Date: 2007-11-05 Impact factor: 4.406
Authors: Jorge Delgado; Rodrigo Toro; Simon Rascovsky; Andres Arango; Gabriel J Angel; Victor Calvo; Jorge A Delgado Journal: Pediatr Radiol Date: 2014-08-21