Literature DB >> 22244444

Oxysterols as non-genomic regulators of cholesterol homeostasis.

Agata A Bielska1, Paul Schlesinger, Douglas F Covey, Daniel S Ory.   

Abstract

Tight regulation of cellular and plasma cholesterol is crucial to proper cellular functioning because excess free cholesterol is toxic to cells and is associated with atherosclerosis and heart disease. Cellular cholesterol homeostasis is regulated by enzymatically formed oxygenated cholesterol derivatives termed oxysterols. Although the effects of oxysterols on transcriptional pathways are well described, the non-transcriptional mechanisms through which oxysterols acutely modulate cellular cholesterol levels are less well understood. We present emerging evidence suggesting that the membrane biophysical properties of oxysterols underlie their acute cholesterol-regulatory functions and discuss the relevance of these acute effects to cholesterol overload in physiological and pathophysiological states. Copyright Â
© 2011 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22244444      PMCID： PMC3294026          DOI： 10.1016/j.tem.2011.12.002

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  58 in total

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Authors:  Nica M Borradaile; Xianlin Han; Jeffrey D Harp; Sarah E Gale; Daniel S Ory; Jean E Schaffer
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2.  Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol.

Authors:  Bao-Liang Song; Norman B Javitt; Russell A DeBose-Boyd
Journal:  Cell Metab       Date:  2005-03       Impact factor: 27.287

3.  Activation of membrane cholesterol by displacement from phospholipids.

Authors:  Yvonne Lange; Jin Ye; Theodore L Steck
Journal:  J Biol Chem       Date:  2005-08-29       Impact factor: 5.157

4.  Pivotal advance: macrophages become resistant to cholesterol-induced death after phagocytosis of apoptotic cells.

Authors:  Dongying Cui; Edward Thorp; Yankun Li; Nan Wang; Laurent Yvan-Charvet; Alan R Tall; Ira Tabas
Journal:  J Leukoc Biol       Date:  2007-06-18       Impact factor: 4.962

5.  Effectors of rapid homeostatic responses of endoplasmic reticulum cholesterol and 3-hydroxy-3-methylglutaryl-CoA reductase.

Authors:  Yvonne Lange; Daniel S Ory; Jin Ye; Michael H Lanier; Fong-Fu Hsu; Theodore L Steck
Journal:  J Biol Chem       Date:  2007-11-16       Impact factor: 5.157

Review 6.  Cholesterol homeostasis and the escape tendency (activity) of plasma membrane cholesterol.

Authors:  Yvonne Lange; Theodore L Steck
Journal:  Prog Lipid Res       Date:  2008-03-29       Impact factor: 16.195

Review 7.  Sterol regulators of cholesterol homeostasis and beyond: the oxysterol hypothesis revisited and revised.

Authors:  Saloni Gill; Renee Chow; Andrew J Brown
Journal:  Prog Lipid Res       Date:  2008-05-06       Impact factor: 16.195

8.  Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig.

Authors:  Arun Radhakrishnan; Yukio Ikeda; Hyock Joo Kwon; Michael S Brown; Joseph L Goldstein
Journal:  Proc Natl Acad Sci U S A       Date:  2007-04-11       Impact factor: 11.205

9.  Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins.

Authors:  Li-Ping Sun; Joachim Seemann; Joseph L Goldstein; Michael S Brown
Journal:  Proc Natl Acad Sci U S A       Date:  2007-04-11       Impact factor: 11.205

10.  How interaction of perfringolysin O with membranes is controlled by sterol structure, lipid structure, and physiological low pH: insights into the origin of perfringolysin O-lipid raft interaction.

Authors:  Lindsay D Nelson; Arthur E Johnson; Erwin London
Journal:  J Biol Chem       Date:  2007-12-17       Impact factor: 5.157
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  19 in total

1.  The structural basis of cholesterol accessibility in membranes.

Authors:  Brett N Olsen; Agata A Bielska; Tiffany Lee; Michael D Daily; Douglas F Covey; Paul H Schlesinger; Nathan A Baker; Daniel S Ory
Journal:  Biophys J       Date:  2013-10-15       Impact factor: 4.033

Review 2.  24(S)-Hydroxycholesterol as a Modulator of Neuronal Signaling and Survival.

Authors:  Min-Yu Sun; Andrew J Linsenbardt; Christine M Emnett; Lawrence N Eisenman; Yukitoshi Izumi; Charles F Zorumski; Steve Mennerick
Journal:  Neuroscientist       Date:  2015-01-27       Impact factor: 7.519

3.  Psychosine, the cytotoxic sphingolipid that accumulates in globoid cell leukodystrophy, alters membrane architecture.

Authors:  Jacqueline A Hawkins-Salsbury; Archana R Parameswar; Xuntian Jiang; Paul H Schlesinger; Ernesto Bongarzone; Daniel S Ory; Alexei V Demchenko; Mark S Sands
Journal:  J Lipid Res       Date:  2013-09-04       Impact factor: 5.922

4.  Synthesis of side-chain oxysterols and their enantiomers through cross-metathesis reactions of Δ22 steroids.

Authors:  David P Brownholland; Douglas F Covey
Journal:  Steroids       Date:  2017-03-12       Impact factor: 2.668

5.  Different oxysterols have opposing actions at N-methyl-D-aspartate receptors.

Authors:  Andrew J Linsenbardt; Amanda Taylor; Christine M Emnett; James J Doherty; Kathiresan Krishnan; Douglas F Covey; Steven M Paul; Charles F Zorumski; Steven Mennerick
Journal:  Neuropharmacology       Date:  2014-05-27       Impact factor: 5.250

6.  Tracking the subcellular fate of 20(s)-hydroxycholesterol with click chemistry reveals a transport pathway to the Golgi.

Authors:  Sara M Peyrot; Sigrid Nachtergaele; Giovanni Luchetti; Laurel K Mydock-McGrane; Hideji Fujiwara; David Scherrer; Andrew Jallouk; Paul H Schlesinger; Daniel S Ory; Douglas F Covey; Rajat Rohatgi
Journal:  J Biol Chem       Date:  2014-03-04       Impact factor: 5.157

7.  Cholesterol through the looking glass: ability of its enantiomer also to elicit homeostatic responses.

Authors:  Ika Kristiana; Winnie Luu; Julian Stevenson; Sian Cartland; Wendy Jessup; Jitendra D Belani; Scott D Rychnovsky; Andrew J Brown
Journal:  J Biol Chem       Date:  2012-08-06       Impact factor: 5.157

8.  Retinal Vascular Abnormalities and Microglia Activation in Mice with Deficiency in Cytochrome P450 46A1-Mediated Cholesterol Removal.

Authors:  Aicha Saadane; Natalia Mast; George Trichonas; Dibyendu Chakraborty; Sandra Hammer; Julia V Busik; Maria B Grant; Irina A Pikuleva
Journal:  Am J Pathol       Date:  2018-11-16       Impact factor: 4.307

9.  Preferential enhancement of GluN2B-containing native NMDA receptors by the endogenous modulator 24S-hydroxycholesterol in hippocampal neurons.

Authors:  Xiaofei Wei; Toshiya Nishi; Shinichi Kondou; Haruhide Kimura; Istvan Mody
Journal:  Neuropharmacology       Date:  2018-12-27       Impact factor: 5.250

Review 10.  The Controversial Role of 24-S-Hydroxycholesterol in Alzheimer's Disease.

Authors:  Paola Gamba; Serena Giannelli; Erica Staurenghi; Gabriella Testa; Barbara Sottero; Fiorella Biasi; Giuseppe Poli; Gabriella Leonarduzzi
Journal:  Antioxidants (Basel)       Date:  2021-05-07
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