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Literature DB >> 22240966

Ternary resin-bound Dynamic Combinatorial Chemistry.

Anna V Gromova¹, Joseph M Ciszewski, Benjamin L Miller.

Abstract

The ability to carry out simultaneous orthogonal exchange chemistries has opened new opportunities for increasing the numerical and structural diversity accessible to Dynamic Combinatorial Chemistry. We present proof-of-concept experiments demonstrating this concept is transferrable to resin-bound DCC, facilitating the generation and analysis of libraries with greater structural diversity. This journal is © The Royal Society of Chemistry 2012

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Year: 2012 PMID： 22240966 PMCID： PMC3652255 DOI： 10.1039/c2cc17192a

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

12 in total

1. Affinity chromatography in dynamic combinatorial libraries: one-pot amplification and isolation of a strongly binding receptor.

Authors: Pol Besenius; Peter A G Cormack; R Frederick Ludlow; Sijbren Otto; David C Sherrington
Journal: Org Biomol Chem Date: 2010-03-19 Impact factor: 3.876

2. The impact of the size of dynamic combinatorial libraries on the detectability of molecular recognition induced amplification.

Authors: R Frederick Ludlow; Sijbren Otto
Journal: J Am Chem Soc Date: 2010-05-05 Impact factor: 15.419

3. Simultaneous and orthogonal covalent exchange processes in dynamic combinatorial libraries.

Authors: Andrea M Escalante; A Gastón Orrillo; Ricardo L E Furlan
Journal: J Comb Chem Date: 2010-07-12

4. Nucleophilic catalysis of hydrazone formation and transimination: implications for dynamic covalent chemistry.

Authors: Anouk Dirksen; Sjoerd Dirksen; Tilman M Hackeng; Philip E Dawson
Journal: J Am Chem Soc Date: 2006-12-13 Impact factor: 15.419

5. Systems chemistry.

Authors: R Frederick Ludlow; Sijbren Otto
Journal: Chem Soc Rev Date: 2007-09-03 Impact factor: 54.564

6. Identification of a selective small-molecule ligand for HIV-1 frameshift-inducing stem-loop RNA from an 11,325 member resin bound dynamic combinatorial library.

Authors: Brian R McNaughton; Peter C Gareiss; Benjamin L Miller
Journal: J Am Chem Soc Date: 2007-08-28 Impact factor: 15.419

7. Two-vial, LC-MS identification of ephedrine receptors from a solution-phase dynamic combinatorial library of over 9000 components.

Authors: R Frederick Ludlow; Sijbren Otto
Journal: J Am Chem Soc Date: 2008-08-21 Impact factor: 15.419

8. Transfer Catalysis Between Two Solids: Application to the Reduction of Nitroarenes.

Authors:
Journal: Angew Chem Int Ed Engl Date: 1999-09 Impact factor: 15.336

9. Dynamic combinatorial selection of molecules capable of inhibiting the (CUG) repeat RNA-MBNL1 interaction in vitro: discovery of lead compounds targeting myotonic dystrophy (DM1).

Authors: Peter C Gareiss; Krzysztof Sobczak; Brian R McNaughton; Prakash B Palde; Charles A Thornton; Benjamin L Miller
Journal: J Am Chem Soc Date: 2008-12-03 Impact factor: 15.419

Ternary resin-bound Dynamic Combinatorial Chemistry.

1. Affinity chromatography in dynamic combinatorial libraries: one-pot amplification and isolation of a strongly binding receptor.

2. The impact of the size of dynamic combinatorial libraries on the detectability of molecular recognition induced amplification.

3. Simultaneous and orthogonal covalent exchange processes in dynamic combinatorial libraries.

4. Nucleophilic catalysis of hydrazone formation and transimination: implications for dynamic covalent chemistry.

5. Systems chemistry.

6. Identification of a selective small-molecule ligand for HIV-1 frameshift-inducing stem-loop RNA from an 11,325 member resin bound dynamic combinatorial library.

7. Two-vial, LC-MS identification of ephedrine receptors from a solution-phase dynamic combinatorial library of over 9000 components.

8. Transfer Catalysis Between Two Solids: Application to the Reduction of Nitroarenes.

9. Dynamic combinatorial selection of molecules capable of inhibiting the (CUG) repeat RNA-MBNL1 interaction in vitro: discovery of lead compounds targeting myotonic dystrophy (DM1).

10. Templated ligand assembly by using G-quadruplex DNA and dynamic covalent chemistry.

1. Fast hydrazone reactants: electronic and acid/base effects strongly influence rate at biological pH.

2. trans-Symmetric Dynamic Covalent Systems: Connected Transamination and Transimination Reactions.

3. Thiazolidinones derived from dynamic systemic resolution of complex reversible-reaction networks.

4. Redox Control over Acyl Hydrazone Photoswitches.

Review 5. Target-Directed Approaches for Screening Small Molecules against RNA Targets.