BACKGROUND: Some hospitals lack facilities for radioisotopes in sentinel node biopsy. A novel method is used with a superparamagnetic tracer and a magnetometer instead of a radioisotope. METHODS: Thirty patients were included in the study after obtaining IRB approval. Superparamagnetic iron oxide and patent blue dye were injected in the subareolar breast tissue. Following a few minutes of massage to promote migration of the iron tracer and blue dye throughout the lymphatic vessels, the axillary lymph nodes were detected transdermally using a handheld magnetometer and followed by standard axillary dissection in all patients. RESULTS: Of 30 patients evaluated, sentinel lymph nodes were identified in 90% (27/30) using both blue dye and magnetic tracer. Sentinel lymph nodes were identified using the magnetic method in 23/30 (77%) and blue dye in 24/30 (80%). There was one false-negative sentinel node, resulting in an overall sensitivity of 6/7 (86%). CONCLUSIONS: This is the first study to use a magnetic tracer to identify sentinel lymph nodes in patients with breast cancer. This new technique may alter the role of radioisotopes with further refinement and experience.
BACKGROUND: Some hospitals lack facilities for radioisotopes in sentinel node biopsy. A novel method is used with a superparamagnetic tracer and a magnetometer instead of a radioisotope. METHODS: Thirty patients were included in the study after obtaining IRB approval. Superparamagnetic iron oxide and patent blue dye were injected in the subareolar breast tissue. Following a few minutes of massage to promote migration of the iron tracer and blue dye throughout the lymphatic vessels, the axillary lymph nodes were detected transdermally using a handheld magnetometer and followed by standard axillary dissection in all patients. RESULTS: Of 30 patients evaluated, sentinel lymph nodes were identified in 90% (27/30) using both blue dye and magnetic tracer. Sentinel lymph nodes were identified using the magnetic method in 23/30 (77%) and blue dye in 24/30 (80%). There was one false-negative sentinel node, resulting in an overall sensitivity of 6/7 (86%). CONCLUSIONS: This is the first study to use a magnetic tracer to identify sentinel lymph nodes in patients with breast cancer. This new technique may alter the role of radioisotopes with further refinement and experience.
Authors: Aidan Cousins; Chris Tsopelas; George Balalis; Sarah K Thompson; Dylan Bartholomeusz; A Bruce Wedding; Benjamin Thierry Journal: J Mater Sci Mater Med Date: 2018-05-29 Impact factor: 3.896
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Authors: Andreas Karakatsanis; Peer Michael Christiansen; Lone Fischer; Christina Hedin; Lida Pistioli; Malin Sund; Nils Ryegaard Rasmussen; Hjørdis Jørnsgård; Daniel Tegnelius; Staffan Eriksson; Kosmas Daskalakis; Fredrik Wärnberg; Christos J Markopoulos; Leif Bergkvist Journal: Breast Cancer Res Treat Date: 2016-04-27 Impact factor: 4.872
Authors: Fei Xie; Dongjie Zhang; Lin Cheng; Lei Yu; Li Yang; Fuzhong Tong; Hongjun Liu; Shu Wang; Shan Wang Journal: World J Surg Oncol Date: 2015-11-19 Impact factor: 2.754
Authors: Elnaz Yaghini; Helen D Turner; Alix M Le Marois; Klaus Suhling; Imad Naasani; Alexander J MacRobert Journal: Biomaterials Date: 2016-07-12 Impact factor: 12.479