Of the four native nucleosides, 2'-deoxyguanosine (dGuo) is most easily oxidized. Two lesions derived from dGuo are 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (Fapy)∙dGuo. Furthermore, while steady-state levels of 8-oxodGuo can be detected in genomic DNA, it is also known that 8-oxodGuo is more easily oxidized than dGuo. Thus, 8-oxodGuo is susceptible to further oxidation to form several hyperoxidized dGuo products. This review addresses the structural impact, the mutagenic and genotoxic potential, and biological implications of oxidatively damaged DNA, in particular 8-oxodGuo, Fapy∙dGuo, and the hyperoxidized dGuo products.
Of the fospan class="Chemical">pan class="Chemical">urspan> native <span>n class="Gene">span class="Chemical">nucleosidespan>, <spapan>n class="Chemical">2'-deoxyguanosine (dGuo) is most easily oxidized. Two lesions derived from <span class="Chemical">dGuo are 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (Fapy)∙dGuo. Furthermore, while steady-state levels of 8-oxodGuo can be detected in genomic DNA, it is also known that 8-oxodGuo is more easily oxidized than dGuo. Thus, 8-oxodGuo is susceptible to further oxidation to form several hyperoxidized dGuo products. This review addresses the structural impact, the mutagenic and genotoxic potential, and biological implications of oxidatively damaged DNA, in particular 8-oxodGuo, Fapy∙dGuo, and the hyperoxidized dGuo products.
Authors: Vilas Mistry; Friederike Teichert; Jatinderpal K Sandhu; Rajinder Singh; Mark D Evans; Peter B Farmer; Marcus S Cooke Journal: Methods Mol Biol Date: 2011
Authors: Nada Al-Tassan; Nikolas H Chmiel; Julie Maynard; Nick Fleming; Alison L Livingston; Geraint T Williams; Angela K Hodges; D Rhodri Davies; Sheila S David; Julian R Sampson; Jeremy P Cheadle Journal: Nat Genet Date: 2002-01-30 Impact factor: 38.330
Authors: Nathalie Müller; Maria Moreno-Villanueva; Arthur Fischbach; Joachim Kienhöfer; Rita Martello; Peter C Dedon; Volker Ullrich; Alexander Bürkle; Aswin Mangerich Journal: Toxicology Date: 2013-05-21 Impact factor: 4.221