Literature DB >> 22238145

Synthetic caged DAG-lactones for photochemically controlled activation of protein kinase C.

Wataru Nomura1, Tetsuo Narumi, Nami Ohashi, Yuki Serizawa, Nancy E Lewin, Peter M Blumberg, Toshiaki Furuta, Hirokazu Tamamura.   

Abstract

Switching on kinases: Synthetic caged DAG-lactones have been developed and showed decreases of two orders of magnitude, relative to the corresponding parent compounds, in their binding affinities towards PKC. The caged compounds had no effect on the translocation of PKC until after photoactivation. This approach is a potentially powerful tool for probing the PKC signaling cascade.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2011        PMID： 22238145      PMCID： PMC8259317          DOI： 10.1002/cbic.201000670

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  36 in total

1.  Photo-mediated gene activation using caged RNA/DNA in zebrafish embryos.

Authors:  H Ando; T Furuta; R Y Tsien; H Okamoto
Journal:  Nat Genet       Date:  2001-08       Impact factor: 38.330

Review 2.  Protein kinase C: structure, function, and regulation.

Authors:  A C Newton
Journal:  J Biol Chem       Date:  1995-12-01       Impact factor: 5.157

3.  Protein kinase C. Modeling of the binding site and prediction of binding constants.

Authors:  S Wang; G W Milne; M C Nicklaus; V E Marquez; J Lee; P M Blumberg
Journal:  J Med Chem       Date:  1994-04-29       Impact factor: 7.446

4.  Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C?

Authors:  K Nacro; B Bienfait; J Lee; K C Han; J H Kang; S Benzaria; N E Lewin; D K Bhattacharyya; P M Blumberg; V E Marquez
Journal:  J Med Chem       Date:  2000-03-09       Impact factor: 7.446

5.  Photo-control of nitric oxide synthase activity using a caged isoform specific inhibitor.

Authors:  Heather J Montgomery; Basil Perdicakis; Dan Fishlock; Gilles A Lajoie; Eric Jervis; J Guy Guillemette
Journal:  Bioorg Med Chem       Date:  2002-06       Impact factor: 3.641

6.  Brominated 7-hydroxycoumarin-4-ylmethyls: photolabile protecting groups with biologically useful cross-sections for two photon photolysis.

Authors:  T Furuta; S S Wang; J L Dantzker; T M Dore; W J Bybee; E M Callaway; W Denk; R Y Tsien
Journal:  Proc Natl Acad Sci U S A       Date:  1999-02-16       Impact factor: 11.205

7.  Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C.

Authors:  P A Wender; C M Cribbs; K F Koehler; N A Sharkey; C L Herald; Y Kamano; G R Pettit; P M Blumberg
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205

8.  Differential binding modes of diacylglycerol (DAG) and DAG lactones to protein kinase C (PK-C).

Authors:  Dina M Sigano; Megan L Peach; Kassoum Nacro; Yongseok Choi; Nancy E Lewin; Marc C Nicklaus; Peter M Blumberg; Victor E Marquez
Journal:  J Med Chem       Date:  2003-04-24       Impact factor: 7.446

9.  Phorbol ester-induced myeloid differentiation is mediated by protein kinase C-alpha and -delta and not by protein kinase C-beta II, -epsilon, -zeta, and -eta.

Authors:  H Mischak; J H Pierce; J Goodnight; M G Kazanietz; P M Blumberg; J F Mushinski
Journal:  J Biol Chem       Date:  1993-09-25       Impact factor: 5.157

10.  Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis.

Authors:  T Ghayur; M Hugunin; R V Talanian; S Ratnofsky; C Quinlan; Y Emoto; P Pandey; R Datta; Y Huang; S Kharbanda; H Allen; R Kamen; W Wong; D Kufe
Journal:  J Exp Med       Date:  1996-12-01       Impact factor: 14.307
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  5 in total

Review 1.  Optochemical Control of Biological Processes in Cells and Animals.

Authors:  Nicholas Ankenbruck; Taylor Courtney; Yuta Naro; Alexander Deiters
Journal:  Angew Chem Int Ed Engl       Date:  2018-02-01       Impact factor: 15.336

2.  Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials.

Authors:  Roy Weinstain; Tomáš Slanina; Dnyaneshwar Kand; Petr Klán
Journal:  Chem Rev       Date:  2020-10-30       Impact factor: 60.622

3.  Synthesis and Evaluation of Dimeric Derivatives of Diacylglycerol-Lactones as Protein Kinase C Ligands.

Authors:  Nami Ohashi; Ryosuke Kobayashi; Wataru Nomura; Takuya Kobayakawa; Agnes Czikora; Brienna K Herold; Nancy E Lewin; Peter M Blumberg; Hirokazu Tamamura
Journal:  Bioconjug Chem       Date:  2017-07-21       Impact factor: 4.774

Review 4.  Structural insights into C1-ligand interactions: Filling the gaps by in silico methods.

Authors:  Sachin Katti; Tatyana I Igumenova
Journal:  Adv Biol Regul       Date:  2021-01-18

5.  A Therapeutic Strategy to Combat HIV-1 Latently Infected Cells With a Combination of Latency-Reversing Agents Containing DAG-Lactone PKC Activators.

Authors:  Kouki Matsuda; Takuya Kobayakawa; Ryusho Kariya; Kiyoto Tsuchiya; Shoraku Ryu; Kohei Tsuji; Takahiro Ishii; Hiroyuki Gatanaga; Kazuhisa Yoshimura; Seiji Okada; Akinobu Hamada; Hiroaki Mitsuya; Hirokazu Tamamura; Kenji Maeda
Journal:  Front Microbiol       Date:  2021-03-17       Impact factor: 5.640
  5 in total

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